Jun 20, 2008

In vivo modulation of sensory input to the olfactory bulb by tonic and activity-dependent presynaptic inhibition of receptor neurons

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nicolás Pírez, Matt Wachowiak

Abstract

The first reorganization of odor representations in the nervous system occurs at the synapse between olfactory receptor neurons and second-order neurons in olfactory bulb glomeruli. Signal transmission at this synapse is modulated presynaptically by several mechanisms, a major one being mediated by GABA(B) receptors, which suppress presynaptic calcium influx and subsequent transmitter release from the receptor neuron terminal. Here, we imaged stimulus-evoked calcium influx into the receptor neuron terminal in anesthetized mice and used odorant and electrical stimulation combined with in vivo pharmacology to characterize the functional determinants of GABA(B)-mediated presynaptic inhibition and to test hypotheses on the role of this inhibition in olfactory processing. As expected from previous studies, blocking presynaptic GABA(B) receptors in vivo increased odorant-evoked presynaptic calcium signals, confirming that GABA(B)-mediated inhibition modulates the strength of receptor inputs. Surprisingly, we found that the strength of this inhibition was affected little by the nature of the input, being independent of the spatial distribution of activated glomeruli, independent of the sniff frequency used to sample the odorant, and s...Continue Reading

Mentioned in this Paper

Presynaptic Terminals
Calcium [EPC]
Structure of Olfactory Bulb
Calcium
Neural Inhibition
Entire Nervous System
Neurons
Brain
Renal Glomerular Disease
Smell Perception

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