In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis

PLoS Pathogens
Lucy C K BellMahdad Noursadeghi

Abstract

Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 responses, indicating that these are not sufficient to protect against disease. Recent findings suggest that favourable outcomes following Mycobacterium tuberculosis infection arise from finely balanced inflammatory and regulatory pathways, achieving pathogen control without immunopathology. We hypothesised that HIV-1 and antiretroviral therapy (ART) exert widespread changes to cell mediated immunity, which may compromise the optimal host protective response to TB and provide novel insights into the correlates of immune protection and pathogenesis. We sought to define these effects in patients with active TB by transcriptional profiling of tuberculin skin tests (TST) to make comprehensive molecular level assessments of in vivo human immune responses at the site of a standardised mycobacterial challenge. We showed that the TST transcriptome accurately reflects the molecular pathology at the site of human pulmonary TB, and used this approach to investigate immune dysregulation in HIV-1/TB co-infected patients with distinct clinical phenotypes assoc...Continue Reading

References

Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Jul 22, 2005·Immunology and Cell Biology·Philippa Hillyer, David Male
Dec 13, 2006·American Journal of Respiratory and Critical Care Medicine·Molebogeng Xheeda RangakaRobert J Wilkinson
Jan 16, 2007·American Journal of Respiratory and Critical Care Medicine·Annie F LuetkemeyerDiane V Havlir
Jan 19, 2008·American Journal of Respiratory and Critical Care Medicine·Stephen D LawnRobin Wood
Jul 26, 2008·The Lancet Infectious Diseases·Graeme MeintjesInternational Network for the Study of HIV-associated IRIS
Mar 24, 2009·Annual Review of Immunology·Sivakumar Vallabhapurapu, Michael Karin
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Apr 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Haileyesus GetahunPaul Nunn
Apr 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin K KellyLionel B Ivashkiv
Jul 3, 2010·EMBO Molecular Medicine·Mi-Jeong KimDavid G Russell
Sep 8, 2010·The European Respiratory Journal·Rebecca TadokeraRobert J Wilkinson
Dec 1, 2010·The Journal of Experimental Medicine·Christof GeldmacherRichard A Koup
Feb 25, 2011·Science Translational Medicine·Paul T G ElkingtonJon S Friedland
Apr 1, 2011·Mucosal Immunology·P S RedfordAnne O'Garra
Aug 2, 2011·European Journal of Immunology·Gillian S TomlinsonMahdad Noursadeghi
Jan 31, 2012·Nucleic Acids Research·Kristoffer S Winther, Kenn Gerdes
May 19, 2012·Nucleic Acids Research·Yuki KatoTatsuya Akutsu
Jun 16, 2012·American Journal of Respiratory and Critical Care Medicine·Graeme MeintjesRobert J Wilkinson
Sep 14, 2012·G3 : Genes - Genomes - Genetics·Andrew T KwonWyeth W Wasserman
Nov 28, 2012·Lung·Cho NaingAni Izzuani Binti Mohd Kassim
Feb 15, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·B J KirengaHarriet Mayanja-Kizza
Sep 13, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·O Morán-MendozaY Ríos-Meza
Oct 22, 2013·Immunity·Steven G DeeksDaniel C Douek
Nov 22, 2013·Nucleic Acids Research·Kim D PruittJames M Ostell
Nov 23, 2013·The Journal of Infectious Diseases·Gillian S TomlinsonMahdad Noursadeghi
Jan 8, 2014·Clinical Microbiology Reviews·Madhukar PaiNiaz Banaei
Apr 11, 2014·The Lancet. Respiratory Medicine·Stefan H E KaufmannMarkus Maeurer
Jul 11, 2014·Cell Host & Microbe·Greg J Towers, Mahdad Noursadeghi
Dec 5, 2014·Science Translational Medicine·Ray Y ChenClifton E Barry
Dec 5, 2014·Science Translational Medicine·M Teresa ColemanJoAnne L Flynn
Jan 15, 2015·Annual Review of Medicine·John J O'SheaArian Laurence
Mar 27, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lucy C K BellMarc Lipman
Jul 18, 2015·Nature Reviews. Drug Discovery·Alimuddin ZumlaRobert S Wallis
Sep 1, 2015·The Lancet Infectious Diseases·Paul T G Elkington, Jon S Friedland
Nov 7, 2015·Investigative Ophthalmology & Visual Science·Thabo LappMahdad Noursadeghi

Citations

Mar 1, 2018·Annual Review of Immunology·Hanif EsmailRobert J Wilkinson
May 29, 2018·Journal of Internal Medicine·S Brighenti, S A Joosten
Nov 8, 2017·Nature Reviews. Microbiology·Lucy C K Bell, Mahdad Noursadeghi
Jan 30, 2019·American Journal of Respiratory and Critical Care Medicine·Keertan DhedaTawanda Gumbo
Jul 29, 2018·Scientific Reports·D ZingueM Drancourt
Jan 4, 2017·PloS One·Gabriele PollaraMahdad Noursadeghi
Nov 12, 2019·Frontiers in Genetics·André N A GonçalvesHelder I Nakaya
Sep 11, 2020·Expert Review of Anti-infective Therapy·Boikobo KesenogileGodfrey Mutashambara Rwegerera
Apr 5, 2018·The Journal of Infectious Diseases·Ekta LachmandasGabriele Pollara
Mar 18, 2021·Frontiers in Immunology·Carolin T TurnerMahdad Noursadeghi

Datasets Mentioned

BETA
E-GEOD-22886

Methods Mentioned

BETA
biopsies
PCA
biopsy
Feature Extraction
ELISA
PCR

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