PMID: 2118956Jul 1, 1990Paper

In vivo morphological damage induced by a new benzimidazole prodrug in Echinococcus multilocularis metacestodes

Journal of Pharmaceutical Sciences
N WalchshoferA F Petavy

Abstract

Benzimidazoles are the most widely used compounds in chemotherapy of alveolar hydatid disease (AHD), but long-term administration is required to reach detectable plasma levels. N-Methoxycarbonyl N'-2-nitro 4-trifluoromethyl phenyl thiourea (2) was prepared as a potential prodrug of (5-trifluoromethyl-1H-benzimidazole-2-yl)-carbamic acid methyl ester. Biological effects of 2 were evaluated in gerbils (Meriones unguiculatus) against the causative agent of AHD, Echinococcus multilocularis metacestodes, through a transmission electron microscopy study. Significant morphological damage of tegument and protoscolices occurred after an 18-day treatment. The treatment of AHD by using the prodrug form of the benzimidazole deserves further study.

Citations

Jun 1, 1996·Surgical Neurology·C TopsakalN Delibalta
Mar 20, 2009·Journal of Helminthology·A Hemphill, J Müller
Sep 17, 2013·Drug Design, Development and Therapy·Carmen LimbanBassem Sadek
Aug 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmen LimbanDiana Camelia Nuță
Jan 1, 1993·Drug Metabolism Reviews·C E Lanusse, R K Prichard

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