In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications

Contrast Media & Molecular Imaging
Paulo Loureiro de SousaEva Tóth

Abstract

Gd(3)L is a trinuclear Gd(3+) complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H(12)L is based on a trimethylbenzene core bearing three methylene-diethylenetriamine- N,N,N'',N''-tetraacetate moieties). Thanks to its appropriate size, the presence of two inner sphere water molecules and a fast water exchange, Gd(3)L has remarkable proton relaxivities at high magnetic field (r(1) = 10.2 vs 3.0 mM(-1) s(-1) for GdDOTA at 9.4 T, 37 degrees C, in H(2)O). Here we report an in vivo MRI feasibility study, complemented with dynamic gamma scintigraphic imaging and biodistribution experiments using the (153)Sm-enriched analog. MRI experiments were performed at 9.4 T in mice with Gd(3)L and the commercial contrast agent gadolinium(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (GdDOTA). Gd(3)L was well tolerated by the animals at the dose of 8 micromol Gd kg(-1) body weight. Dynamic contrast enhanced (DCE) images showed considerably higher signal enhancement in the kidney medulla and cortex after Gd(3)L injection than after GdDOTA injection at an identical dose. The relaxation rates, DeltaR(1), were calculated from the IR TrueFISP data. During the excretory phase, t...Continue Reading

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Citations

Nov 22, 2011·Journal of Medicinal Chemistry·Luca FrullanoYanming Wang
Mar 24, 2011·Future Medicinal Chemistry·Allison S Harney, Thomas J Meade
Oct 31, 2012·Contrast Media & Molecular Imaging·Miguel F FerreiraCarlos F G C Geraldes
Jan 4, 2012·Chemistry : a European Journal·Célia S BonnetÉva Tóth
Dec 22, 2014·Journal of Inorganic Biochemistry·Kristina Djinovic-Carugo, Oliviero Carugo
Oct 28, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Vojtech KubícekLoïc Charbonnière
Mar 16, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Böer-Auer, D Metze
Jun 13, 2020·Chemical Communications : Chem Comm·Harwinder SinghAmitava Das

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