In vivo MRI of cartilage pathogenesis in surgical models of osteoarthritis.

Skeletal Radiology
Didier LaurentTheodore Pellas

Abstract

To examine in vivo time-course changes in macromolecular composition of articular cartilage in two surgical models of osteoarthritis (goat: meniscal transection and cartilage incision; rabbit: medial meniscectomy). Collagen integrity and proteoglycan (PG) content were evaluated in both models by magnetization transfer (MT) and contrast-enhanced MRI, respectively. The MT rate k(m) for the exchange process between the bulk water and water bound to collagen was determined as a marker of the collagen network. Local changes in cartilage fixed charge density, i.e., where PGs are depleted, were derived from T(1) relaxation maps as obtained after an infusion of Gd(DTPA)(2-), a paramagnetic agent. In the goat model, the MT rate constant k(m) was significantly higher at 2 weeks post surgery, a possible sign of cartilage swelling, then decreased below baseline values, most likely indicative of disruption in the collagen framework. Meanwhile, post-Gd(DTPA)(2-) MRI acquisition indicated a significant and sustained loss of PGs. The rabbit model produced milder lesions. Although the difference was non-significant, k(m) steadily decreased in response to the surgical insult while kinetics of Gd(DTPA)(2-) uptake, after reaching a peak level at 6...Continue Reading

References

Mar 4, 1991·Biochimica Et Biophysica Acta·A MaroudasP Weinberg
May 1, 1973·Arthritis and Rheumatism·R W MoskowitzV H Frankel
Feb 1, 1984·Arthritis and Rheumatism·J M Williams, K D Brandt
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J Stanisz, R M Henkelman
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amy GillisDeborah Burstein
May 28, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Didier LaurentTheodore Pellas
Aug 27, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Didier LaurentMarkus Rudin

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Citations

Jan 18, 2013·Arthritis·Martin H GregorySeth L Sherman
Jan 5, 2012·EJNMMI Research·Jordi L TremoledaWilly Gsell
Dec 3, 2014·Magnetic Resonance Imaging Clinics of North America·Richard Kijowski, Rajeev Chaudhary
Jun 15, 2011·Magnetic Resonance Imaging Clinics of North America·Jung-Ah Choi, Garry E Gold
Jul 22, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wei LiPottumarthi V Prasad
Apr 26, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth W FishbeinRichard G Spencer
Jan 19, 2017·Tissue Engineering and Regenerative Medicine·Ji-Yun KoGun-Il Im

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