PMID: 8585094Sep 1, 1995Paper

In vivo neutralization of tetrodotoxin by a monoclonal antibody

Toxicon : Official Journal of the International Society on Toxinology
K Matsumura

Abstract

This study examined the ability of monoclonal antibody against TTX to neutralize tetrodotoxin (TTX) in vivo. The mice were injected i.p. with 1.5 mouse units of TTX, followed 3 min later by administering graded doses of antibody immunoglobulin G (IgG). Animals injected with 100 micrograms IgG through the tail vein showed 100% survival. The 50% protective dose was c. 2 mg/kg. The present results indicate that monoclonal antibody can neutralize TTX in vivo.

References

Jun 1, 1978·Australian Veterinary Journal·R B Atwell, G B Stutchbury
Dec 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·S Fukiya, K Matsumura
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·S WatabeK Yamauchi

❮ Previous
Next ❯

Related Concepts

Related Feeds