PMID: 8586903Nov 1, 1995Paper

In-vivo NMR thermometry with liposomes containing 59Co complexes

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
A G WebbK S Suslick

Abstract

The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of it 59Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 degrees C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.

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Citations

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T FrenzelH J Weinmann
Nov 14, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K KurodaF A Jolesz
Oct 28, 1998·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M HentschelR Felix
Jan 14, 1999·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J T ChangM Fanning
Oct 17, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark W Dewhirst
Sep 9, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J GellermannP Wust
Sep 9, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·L H LindnerM Peller
Jul 1, 1996·Journal of Magnetic Resonance Imaging : JMRI·A G WebbK S Suslick
Oct 26, 1999·Physics in Medicine and Biology·M HentschelR Felix
Jun 13, 2003·Journal of Interventional Cardiology·Leonidas Diamantopoulos
Aug 2, 2019·Chemical Science·Tyler M OzvatJoseph M Zadrozny

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