In vivo normative atlas of the hippocampal subfields using multi-echo susceptibility imaging at 7 Tesla

Human Brain Mapping
Maged GoubranAli R Khan

Abstract

To generate a high-resolution atlas of the hippocampal subfields using images acquired from 7 T, multi-echo, gradient-echo MRI for the evaluation of epilepsy and neurodegenerative disorders as well as investigating R2* (apparent transverse relaxation rate) and quantitative volume magnetic susceptibility (QS) of the subfields. Healthy control subjects (n=17) were scanned at 7 T using a multi-echo gradient-echo sequence and susceptibility-weighted magnitude images, R2* and QS maps were reconstructed. We defined a hippocampal subfield labeling protocol for the magnitude image produced from the average of all echoes and assessed reproducibility through volume and shape metrics. A group-wise diffeomorphic registration procedure was used to generate an average atlas of the subfields for the whole subject cohort. The quantitative MRI maps and subfield labels were then warped to the average atlas space and used to measure mean values of R2* and QS characterizing each subfield. We were able to reliably label hippocampal subfields on the multi-echo susceptibility images. The group-averaged atlas accurately aligns these structures to produce a high-resolution depiction of the subfields, allowing assessment of both quantitative susceptibil...Continue Reading

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Citations

Mar 13, 2015·NMR in Biomedicine·Wietske van der ZwaagRobert Trampel
Jul 4, 2015·Journal of Neurology·Juri-Alexander WittChristoph Helmstaedter
Sep 1, 2015·NeuroImage·Christine Lucas TardifPierre-Louis Bazin
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May 27, 2016·Annals of Neurology·Boris C BernhardtNeda Bernasconi
Dec 10, 2015·Neurosurgical Focus·Rohaid AliMichael M Zeineh
Dec 19, 2015·Human Brain Mapping·Maged GoubranAli R Khan
Nov 26, 2015·Scientific Data·Jessie Kulaga-YoskovitzNeda Bernasconi
Feb 3, 2016·NMR in Biomedicine·Kawin SetsompopJonathan R Polimeni
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Aug 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Brendan G SantyrAli R Khan
Apr 22, 2018·Current Treatment Options in Neurology·Tim SinneckerRegina Schlaeger
Jul 14, 2019·Epilepsy & Behavior : E&B·Carlo RondinoniEdson Amaro
Mar 3, 2021·NeuroImage. Clinical·R H G J van LanenO E M G Schijns
Mar 8, 2021·NeuroImage·Aurélie BussyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
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Mar 23, 2021·Seizure : the Journal of the British Epilepsy Association·Katja MenzlerSusanne Knake
Jul 31, 2021·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Fateme SalehiAli R Khan

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