In vivo optic nerve head mechanical response to intraocular and cerebrospinal fluid pressure: imaging protocol and quantification method

Scientific Reports
Massimo A FazioChristopher A Girkin

Abstract

This study presents a quantification method for the assessment of the optic nerve head (ONH) deformations of the living human eye under acute intraocular pressure (IOP) elevation and change of cerebrospinal fluid pressure (CSFP) with body position. One eye from a brain-dead organ donor with open-angle glaucoma was imaged by optical coherence tomography angiography during an acute IOP and CSFP elevation test. Volumetric 3D strain was computed by digital volume correlation. With increase in IOP the shear strain consistently increased in both sitting and supine position (p < 0.001). When CSFP was increased at constant IOP by changing body position, a global reduction in the ONH strain was observed (-0.14% p = 0.0264). Strain in the vasculature was significantly higher than in the structural tissue (+0.90%, p = 0.0002). Retinal nerve fiber layer (RNFL) thickness strongly associated (ρ = -0.847, p = 0.008) with strain in the peripapillary sclera (ppScl) but not in the retina (p = 0.433) and lamina (p = 0.611). These initial results show that: CSFP independently to IOP modulates strain in the human ONH; ppScl strains are greater than strains in lamina and retina; strain in the retinal vasculature was higher than in the structural tis...Continue Reading

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Citations

Mar 6, 2019·Investigative Ophthalmology & Visual Science·Yanhui MaJun Liu
Mar 27, 2019·The British Journal of Ophthalmology·Yong Woo Kim, Ki Ho Park
May 16, 2019·Tissue Engineering. Part B, Reviews·Pascal A M M VroemenJan de Boer
Jan 3, 2019·Investigative Ophthalmology & Visual Science·Brad Fortune
Nov 10, 2020·Investigative Ophthalmology & Visual Science·Andrew P VoorheesIan A Sigal
Aug 15, 2019·Progress in Retinal and Eye Research·Craig BooteMichael J A Girard
Jan 29, 2020·Progress in Retinal and Eye Research·Alon HarrisJulia Arciero
Feb 18, 2021·Journal of Glaucoma·Eric ChanRobert N Weinreb
Jul 18, 2019·Archivos de la Sociedad Española de Oftalmología·F J García-CallejoJ R Alba García

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Software Mentioned

HEYEX
Heidelberg HEYEX TM
Multiview
SPX
NLME package - R - Foundation for Statistical Computing
DaVis
Mathematica

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