In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign

The Journal of Dermatology
Giorgia CapocasaleGiuseppina Campisi

Abstract

There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive, repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-year-old patient with desquamative gingivitis. However, a negative Nikolsky's sign did not seem to indicate a diagnosis of mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisional biopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining of tomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky's sign, thereby enabling the clinician to identify the presence (or not) of subepithelial bullae. Thereafter, an assessment of changes in the subepithelium (the split) can be performed, even in the absence of a suitable clinical picture, such as, for example, a negative Nikolsky's sign. Histological analysis and the use of indirect immunofluorescence have facilitated a diagnosis of mucous membrane pemphigoid, an autoimmune pathology, which can be confirmed with the appearance of subepithelial bullae. OCT was found to be a valid, non-invasive, auxiliary diagnostic device, capable of r...Continue Reading

References

Jun 6, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Miguel Angel Gonzalez-MolesManuel Bravo
May 25, 2007·Journal of Cellular and Molecular Medicine·Sidonia Mihai, Cassian Sitaru
Sep 7, 2007·The British Journal of Oral & Maxillofacial Surgery·Crispian Scully, Lorenzo Lo Muzio
Sep 25, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·M MogensenG B E Jemec
Dec 5, 2008·Journal of Periodontology·Michele D MignognaSergio Matarasso
Sep 4, 2009·The British Journal of Oral & Maxillofacial Surgery·Waseem JerjesColin Hopper
Sep 25, 2009·International Journal of Dermatology·Lucio Lo RussoGiuseppina Campisi
Jun 8, 2012·Head & Neck Oncology·Zaid HamdoonColin Hopper
Mar 8, 2013·Photodiagnosis and Photodynamic Therapy·Zaid HamdoonColin Hopper
Mar 8, 2016·The Journal of Dermatology·Victor Desmond MandelGiovanni Pellacani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.