In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humans

Journal of Biophotonics
Evgeny A ShirshinMaxim E Darvin

Abstract

Heart failure (HF) is among the socially significant diseases, involving over 2% of the adult population in the developed countries. Diagnostics of the HF severity remains complicated due to the absence of specific symptoms and objective criteria. Here, we present an indicator of the HF severity based on the imaging of tissue parameters around the nailfold capillaries. High resolution nailfold video capillaroscopy was performed to determine the perivascular zone (PZ) size around nailfold capillaries, and 2-photon tomography with fluorescence lifetime imaging was used to investigate PZ composition. We found that the size of PZ around the nailfold capillaries strongly correlates with HF severity. Further investigations using 2-photon tomography demonstrated that PZ corresponds to the border of viable epidermis and it was suggested that the PZ size variations were due to the different amounts of interstitial fluid that potentially further translates in clinically significant oedema. The obtained results allow for the development of a quantitative indicator of oedematous syndrome, which can be used in various applications to monitor the dynamics of interstitial fluid retention. We therefore suggest PZ size measured with nailfold vi...Continue Reading

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Citations

Jul 7, 2019·Clinical Rheumatology·Abdolamir KarbalaieBjörn-Erik Erlandsson
Aug 28, 2019·Biomedical Optics Express·Andrei E LugovtsovAlexander V Priezzhev
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexey N SemenovEvgeny A Shirshin

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