PMID: 6159811Oct 1, 1980Paper

In vivo oxygen dissociation curves in transfused and untransfused newborns with cardiopulmonary disease

The American Review of Respiratory Disease
A R WilkinsonH T Versmold

Abstract

We used a new, rapidly responding in vivo catheter oximeter to continuously measure arterial oxygen saturation (Sao2) in 34 newborns with cardiopulmonary disease. The Sao2 was compared with the oxygen tension (Pao2) of blood sampled through the catheter in 2 groups. We evaluated the oxygen dissociation curves of 24 untransfused infants whose hemoglobin F (HbF) concentration was greater than or equal to 80%. We also examined the Sao2 curves of 20 extensively transfused infants who had greater than or equal to 80% hemoglobin A (HbA). We found a wide variation in Sao2 at levels of arterial Po2 between 30 and 90 mmHg. Although the oxygen dissociation curve of the transfused group was significantly to the right of the untransfused group, there was considerable overlapping between the 2 curves. This dispersion reflected the wide range of clinical states encountered in newborns with cardiopulmonary disease, and the changes in blood oxygen affinity. In some newborns, when Pao2 was less than 50 mmHg, Sao2 could be > 90% whereas in others, Sao2 could be < 75%. When both Pao2 and Sao2 were low, Sao2 reflected arterial oxygen contents more precisely because of the shape of the individual oxygen dissociation curves in both groups. Opinions ...Continue Reading

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