In vivo percutaneous absorption of benzene in man: forearm and palm

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Bobeck S Modjtahedi, Howard I Maibach

Abstract

The exact role topical exposure to benzene plays in its hazard profile remains incompletely defined. This investigation explores the amount of benzene absorbed through human skin in vivo following one direct topical application to the forearm or palm. Absorption values were found to be nominal with forearm exposure showing an average total absorption of 0.07+/-0.04% and palmar exposure an average total absorption of 0.13+/-0.04% of the applied dose. Differences in excretion and absorption between the surfaces were not found to be within statistical significance. This is in contrast to previous studies that found greater absorption through the forearm than palm. Although total absorption values were small, these findings were gathered in an idealized environment where benzene was present in pure solution and applied only once to non-damaged skin. Therefore, these findings could underestimate benzene flux as many exposure conditions occur and many skin variables exist. Generalization of the data must be taken with caution.

References

Sep 1, 1981·Archives of Environmental Health·H I Maibach, D M Anjo
May 29, 2000·International Journal of Occupational and Environmental Health·R C Wester, H I Maibach

❮ Previous
Next ❯

Citations

Apr 2, 2011·Skin Pharmacology and Physiology·P A LehmanT J Franz
Feb 4, 2011·Critical Reviews in Toxicology·Pamela R D WilliamsAnnette L Bunge
Feb 6, 2014·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kenneth T Bogen, Patrick J Sheehan
May 21, 2013·International Journal of Occupational and Environmental Health·Pamela R D WilliamsJohn Spencer
Jan 26, 2013·Critical Reviews in Toxicology·Scott M ArnoldA Robert Schnatter
Nov 29, 2013·Journal of Occupational and Environmental Hygiene·Rosalie TibaldiDaniel Drolet
Aug 10, 2017·Journal of Exposure Science & Environmental Epidemiology·H Frederick Frasch, Ana M Barbero
Aug 26, 2021·Toxicology Reports·Nayyer Golabi-HabashiHassan Malekinejad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Archives of Occupational and Environmental Health
K EngströmV Riihimäki
British Journal of Industrial Medicine
T Dutkiewicz, H Tyras
British Journal of Industrial Medicine
T Dutkiewicz, H Tyras
© 2021 Meta ULC. All rights reserved