In vivo performance of a sol-gel glass-coated collagen

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Angela Leão AndradeRosana Zacarias Domingues

Abstract

Synthetic bioactive materials offer possibilities to repair large tissue defects. It is well known that bioactivity, angiogenesis, and inflammation are key events in implant incorporation. Using glass-coated and glass-free collagen as potential bone graft substitutes, we carried out in vitro bioactivity and an in vivo angiogenesis and inflammation studies. The in vitro study showed bioactivity when the glass-coated samples were left in SBF for 5 days. This was confirmed by FTIR results, which presented P--O vibration bands characteristic of hydroxyapatite close to 1060 cm(-1) and 600 cm(-1). The in vivo response was evaluated following subcutaneous implantation of the biomaterial in the mouse dorsa. Angiogenesis, as determined by hemoglobin content extracted from implants 7 and 14 days after implantation, increased progressively in both glass-coated and glass-free collagen implants. However, vascularization was higher in the glass-coated collagen implants 14 days after implantation (mug Hb per mg wet tissue 6.0 +/- 0.3) compared with the glass-free group (1.6 +/- 0.1). The inflammatory process, determined by the levels of myeloperoxidase and N-acetylglucosaminidase, was similar for both implants. This study shows that glass-coa...Continue Reading

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Citations

Dec 26, 2015·Journal of Materials Science. Materials in Medicine·S A ClarkeF Buchanan
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·L-C GerhardtA R Boccaccini
Aug 15, 2014·Advanced Healthcare Materials·Bapi SarkerAldo R Boccaccini
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Jul 6, 2010·Materials·Lutz-Christian Gerhardt, Aldo R Boccaccini
May 7, 2010·Biomacromolecules·Benedetto MarelliShowan N Nazhat

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