In vivo PET imaging of neuroinflammation in Alzheimer's disease

Journal of Neural Transmission
Julien LagardeMichel Bottlaender

Abstract

Increasing evidence suggests that neuroinflammation contributes to the pathophysiology of many neurodegenerative diseases, especially Alzheimer's disease (AD). Molecular imaging by PET may be a useful tool to assess neuroinflammation in vivo, thus helping to decipher the complex role of inflammatory processes in the pathophysiology of neurodegenerative diseases and providing a potential means of monitoring the effect of new therapeutic approaches. For this objective, the main target of PET studies is the 18 kDa translocator protein (TSPO), as it is overexpressed by activated microglia. In the present review, we describe the most widely used PET tracers targeting the TSPO, the methodological issues in tracer quantification and summarize the results obtained by TSPO PET imaging in AD, as well as in neurodegenerative disorders associated with AD, in psychiatric disorders and ageing. We also briefly describe alternative PET targets and imaging modalities to study neuroinflammation. Lastly, we question the meaning of PET imaging data in the context of a highly complex and multifaceted role of neuroinflammation in neurodegenerative diseases. This overview leads to the conclusion that PET imaging of neuroinflammation is a promising wa...Continue Reading

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Citations

Nov 9, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jefferson W KinneyBruce T Lamb
Jul 29, 2020·Frontiers in Physiology·Daniela LiccardoAlessandro Cannavo
Aug 23, 2018·Frontiers in Neurology·Paul EdisonMagdalena Sastre
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Aug 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Fabien ChauveauHervé Boutin
Nov 2, 2021·Journal of Neurology·Peng-Fei Zhang, Fan Gao

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