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In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Alexander J LepakDavid R Andes

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Abstract

Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target PK/PD exposures a...read more

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Bacterial Proteins
Neutropenia
Drug Kinetics
Plasma
Staphylococcus aureus
Evaluation
Pharmacodynamics
Methicillin resistant Staphylococcus aureus (organism)
In Vivo
Methicillin susceptible Staphylococcus aureus (organism)
1
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In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Alexander J LepakDavid R Andes

PMID: 31712210

DOI: 10.1128/aac.02058-19

Abstract

Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target PK/PD exposures a...read more

Mentioned in this Paper

Bacterial Proteins
Neutropenia
Drug Kinetics
Plasma
Staphylococcus aureus
1

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