May 1, 2019

In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model

Antimicrobial Agents and Chemotherapy
Alexander J LepakDavid R Andes

Abstract

Omadacycline is a novel aminomethylcycline antibiotic with potent activity against Staphylococcus aureus, including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in a neutropenic murine thigh model. The median 24-h area under the concentration-time curve (AUC)/MIC values associated with net stasis and 1-log kill were 21.9 and 57.7, respectively.

Mentioned in this Paper

In Vivo
Neutropenia
Methicillin resistant Staphylococcus aureus (organism)
Neutropenic Infection
Staphylococcus aureus
omadacycline
Methicillin
SLC9A6
Antibiotics
Stasis

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