In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning.

Neuropharmacology
Kyle A VickRobert Stackman

Abstract

Small conductance Ca(2+)-activated K(+) channels (SK, K(Ca2.1), K(Ca2.2), K(Ca2.3)) are expressed at high levels in brain regions critical for learning and memory. The activation of dendritic SK channels limits the induction of synaptic plasticity that may underlie hippocampal and amygdala dependent memory. EBIO facilitates SK channel activation by increasing their sensitivity to calcium. The compound CyPPA selectively activates SK2 and SK3 channels in a similar manner. To date there has been no report of the effects of SK channel activators on memory. Therefore, the present study examined the effects of systemic EBIO on mice in a behavioral task battery. Significant effects of EBIO on memory and motor activity were validated and extended by examining the effects of systemic CyPPA. Systemic EBIO and CyPPA both produced a transient decline in locomotor behavior. Neither SK channel activator affected anxiety. EBIO (17.5 mg/kg) impaired the encoding, but not retrieval, of object memory in a spontaneous object recognition task. A similar impairment of object memory encoding was observed in CyPPA (15 mg/kg)-treated mice. These memory-impairing effects were not due to changes in motivation, attention or movement. Systemic EBIO did no...Continue Reading

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Citations

May 4, 2012·Journal of Neurophysiology·Bridget M McKayJohn F Disterhoft
Apr 6, 2011·PloS One·Stefan LiebauTobias M Boeckers
Sep 29, 2011·Annual Review of Physiology·John P AdelmanPankaj Sah
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Jul 14, 2020·Frontiers in Genetics·Miriam KessiFei Yin
Jul 7, 2017·Neuron·Heather K TitleyChristian Hansel

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