PMID: 6405075Mar 1, 1983Paper

In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients

Kidney International
G FramptonJ S Cameron

Abstract

Renal allograft recipients were investigated to determine the extent and possible nature of in vivo platelet activation. In 92 allografted patients stable for more than 4 months' duration, intraplatelet serotonin in circulating platelets was depleted significantly. In a further 16 patients studied serially for 12 to 16 weeks following transplantation, intraplatelet serotonin fell abruptly within 4 days from transplantation to very low levels, and remained thus for 10 weeks, rising toward normal at about 12 weeks. Although some patients showed abrupt falls in intraplatelet serotonin coincident with acute rejection episodes, there was no difference in intraplatelet serotonin in seven patients whose grafts functioned well immediately and remained stable, and seven in whom repeated rejection led to graft loss within 3 months. Thus, these tests of platelet function do not permit diagnosis of rejection or prediction of graft outcome. Plasma platelet factor 4 (PF4) concentrations, in contrast, were normal in most patients during the first 6 weeks after grafting, then rose and remained abnormal up to 13 years following the allograft in the long-term stable graft recipients. This discrepancy suggests a different mode of platelet activat...Continue Reading

References

Jan 1, 1979·Annual Review of Medicine·H Holmsen, H J Weiss
Jun 1, 1978·Cell·R Ross, A Vogel
Jan 1, 1979·Thrombosis Research·A Parbtani, J S Cameron
Jan 1, 1979·Thrombosis Research·G RemuzziM J Silver
Jan 1, 1979·Journal of Supramolecular Structure·B R Zetter, H N Antoniades
Apr 1, 1976·Transplantation·T PalosuoF Milgrom
Dec 30, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W WagnerF Huth
Jan 1, 1976·Thrombosis Research·A E BoltonJ D Cash
Jan 1, 1974·Thrombosis Research·D L BallantyneR J Coburn
Nov 21, 1974·The New England Journal of Medicine·C R GeorgeL A Harker
Sep 25, 1969·The New England Journal of Medicine·R W ColmanJ P Merrill
Aug 1, 1980·Science·I D GoldbergR I Handin
Jun 1, 1980·Transplantation·J EgidoL Hernando
Jul 1, 1980·Histopathology·H C HsuE Grishman
Feb 1, 1981·Kidney International·K V JohnyJ B Dossetor
Aug 1, 1980·The American Journal of Medicine·F I ParetiP M Mannucci
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS

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Citations

Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Nov 23, 2013·Journal of Thrombosis and Thrombolysis·Kristina L Modjeski, Craig N Morrell
Feb 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M de LorgerilS Renaud

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