Jul 17, 2019

In vivo Prevalence of Alzheimer Biomarkers in Dementia with Lewy Bodies

Dementia and Geriatric Cognitive Disorders
George P ParaskevasElisabeth Kapaki

Abstract

Neuropathological studies indicate concomitant Alzheimer's disease (AD) pathology in patients with dementia with Lewy bodies (DLB). To measure cerebrospinal fluid (CSF) levels of β-amyloid peptide with 42 amino acids (Aβ42), total tau protein (τT), and tau phosphorylated at threonine 181 (τP-181) in 38 patients fulfilling the diagnostic criteria of probable DLB according to the most recent (4th consensus) report. Double-sandwich commercial ELISAs (Innotest; Fujirebio, Gent, Belgium) were used for measurements. According to the current cutoff values of our laboratory, 4 biomarker profiles were noted: abnormal levels of Aβ42 only (44.7%), full AD profile (39.5%), abnormal levels of τT only (5.3%), and normal levels of all 3 biomarkers (10.5%). AD profile was associated with female sex, older age, lower education, and lower MMSE scores. Reduction in Αβ42 in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression.

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Mentioned in this Paper

Mini-mental State Examination
Biological Markers
Study
In Vivo
Granulocyte Colony-Stimulating Factor
Laboratory
Cerebrospinal Fluid
Alzheimer's Disease
Lewy Bodies
Dementia

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