In vivo probe-based confocal laser endomicroscopy in chronic interstitial lung diseases: Specific descriptors and correlation with chest CT

Respirology : Official Journal of the Asian Pacific Society of Respirology
Mathieu SalaünLuc Thiberville

Abstract

Probe-based confocal laser endomicroscopy (pCLE) enables in vivo microimaging of the distal lung, during bronchoscopy. This study aims at identifying pCLE descriptors of chronic interstitial lung diseases (ILD), their correlations with chest HRCT and assessing inter-observer agreement. pCLE was performed in 21 healthy volunteers (HV) and 59 non-smoking ILD patients, including 19 patients with idiopathic pulmonary fibrosis (IPF) or asbestosis, 15 with connective tissue disease-associated ILD (CTD-ILD), 17 with sarcoidosis and 8 with hypersensitivity pneumonitis (HP). pCLE descriptors were identified in ILD on the basis of comparison with HV. Nine pCLE descriptors were more frequent in ILD compared to HV, with good inter-observer agreement, including fluorescent bronchiolar cells (sarcoidosis, CTD-ILD and HP), fluorescent alveolar cells (CTD-ILD and HP), small alveolar entrance rings (IPF or asbestosis and CTD-ILD), enlarged axial elastic fibres (IPF or asbestosis), septal fibres (IPF or asbestosis, CTD-ILD and HP), disorganized acinar network and rigid acinar network (IPF or asbestosis and CTD-ILD), dense elastic network (IPF or asbestosis) and alveolar fluorescent nodular structures (in sarcoidosis) (P < 0.01, Fisher's exact te...Continue Reading

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Citations

Jun 19, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Athol U Wells
Mar 19, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Peter M George, Athol U Wells
Aug 14, 2019·Journal of Clinical Medicine·Olivier LesurMartin Lepage
Dec 2, 2020·Optics Letters·Helen E ParkerMichael G Tanner
Sep 19, 2020·The European Respiratory Journal·Thomas VilleneuveGrégoire Prévot
Oct 17, 2020·The European Respiratory Journal·Susan FernandesKevin Dhaliwal
Apr 10, 2021·ERJ Open Research·Thibault ViatgéNicolas Guibert
May 22, 2020·La Presse médicale·Vincent Cottin, Claudia Valenzuela

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