In vivo proliferative regeneration of balance hair cells in newborn mice.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Joseph C BurnsJeffrey T Corwin

Abstract

The regeneration of mechanoreceptive hair cells occurs throughout life in non-mammalian vertebrates and allows them to recover from hearing and balance deficits that affect humans and other mammals permanently. The irreversibility of comparable deficits in mammals remains unexplained, but often has been attributed to steep embryonic declines in cellular production. However, recent results suggest that gravity-sensing hair cells in murine utricles may increase in number during neonatal development, raising the possibility that young mice might retain sufficient cellular plasticity for mitotic hair cell regeneration. To test for this we used neomycin to kill hair cells in utricles cultured from mice of different ages and found that proliferation increased tenfold in damaged utricles from the youngest neonates. To kill hair cells in vivo, we generated a novel mouse model that uses an inducible, hair cell-specific CreER allele to drive expression of diphtheria toxin fragment A (DTA). In newborns, induction of DTA expression killed hair cells and resulted in significant, mitotic hair cell replacement in vivo, which occurred days after the normal cessation of developmental mitoses that produce hair cells. DTA expression induced in 5-...Continue Reading

References

Jun 24, 1988·Science·J T Corwin, D A Cotanche
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J T Corwin
Oct 1, 1981·The Journal of Comparative Neurology·J T Corwin
May 8, 1995·The Journal of Comparative Neurology·L LiA Forge
Jun 19, 1996·Annals of the New York Academy of Sciences·R A BairdN R Schuff
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L Li, A Forge
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LöwenheimH P Zenner
Sep 11, 2001·Journal of the Association for Research in Otolaryngology : JARO·J I MatsuiE W Rubel
Jun 20, 2003·The Journal of Comparative Neurology·Elizabeth C OesterleEdwin W Rubel
Sep 2, 2003·Nature Medicine·Huawei LiStefan Heller
Dec 24, 2003·Journal of the Association for Research in Otolaryngology : JARO·Clifford R HumeElizabeth C Oesterle
Oct 1, 2005·The Journal of Comparative Neurology·Mette Kirkegaard, Jens R Nyengaard
Nov 4, 2005·Genesis : the Journal of Genetics and Development·Anna IvanovaJuan Pedro Martinez-Barbera
Sep 8, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lionel M L ChowSuzanne J Baker
Dec 16, 2006·Journal of the Association for Research in Otolaryngology : JARO·Kazuo OshimaStefan Heller
Mar 3, 2007·The European Journal of Neuroscience·Dawn DaviesJeffrey T Corwin
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R Meyers, Jeffrey T Corwin
Sep 25, 2007·The International Journal of Developmental Biology·Jennifer S Stone, Douglas A Cotanche
Jan 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thomas WeberJian Zuo
May 13, 2008·Developmental Neurobiology·Zhenjie Lu, Jeffrey T Corwin
Aug 2, 2008·Science·Bjarke AbrahamsenJohn N Wood
Sep 24, 2008·Hearing Research·Kohei KawamotoYehoash Raphael
Nov 6, 2008·Journal of Physiology, Paris·Günther K H Zupanc
May 28, 2009·Nature Neuroscience·John V Brigande, Stefan Heller
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yiling YuJian Zuo
Aug 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Sol ColladoJeffrey T Corwin
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent LinJennifer S Stone
Nov 22, 2011·Stem Cells·Mohammad RonaghiStefan Heller

❮ Previous
Next ❯

Citations

Jun 4, 2013·Annual Review of Neuroscience·Andrew K GrovesDonna M Fekete
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin S GolubJennifer S Stone
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcia M Mellado LagardeJian Zuo
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Olivia Bermingham-McDonoghThomas A Reh
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tiantian CaiAndrew K Groves
Nov 24, 2012·British Medical Bulletin·Marcelo N Rivolta
Jan 31, 2016·Developmental Biology·Amber D Slowik, Olivia Bermingham-McDonogh
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wenyan LiHuawei Li
Jun 4, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eric L SlatteryMark E Warchol
Jul 22, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mark E Lush, Tatjana Piotrowski
May 27, 2015·Molecular Neurobiology·Yingzi HeHuawei Li
Jul 24, 2013·Hearing Research·Fabio GaspariniLucia Manni
Apr 18, 2015·Frontiers in Cellular Neuroscience·Jinchao LinWeinian Lin
Mar 31, 2015·Frontiers in Cellular Neuroscience·Lina JanssonAlan G Cheng
Feb 11, 2014·Developmental Biology·Esther C MaierTanya T Whitfield
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Marcia M Mellado LagardeGabriel Corfas
May 18, 2016·Frontiers of Medicine·Wenyan LiHuawei Li
Jun 9, 2016·Current Opinion in Genetics & Development·Jonathan S KnissTatjana Piotrowski
Feb 12, 2017·Chonnam Medical Journal·Sungsu LeeHyong-Ho Cho
Jul 26, 2017·ELife·Ksenia GnedevaA J Hudspeth
Jul 26, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Zahra N SayyidAlan G Cheng
Mar 27, 2015·Journal of Neurophysiology·Yohan SongJohn S Oghalai
Dec 26, 2018·Expert Opinion on Biological Therapy·Patrick J AtkinsonAlan G Cheng
Sep 26, 2019·Annual Review of Cell and Developmental Biology·Nicolas DenansTatjana Piotrowski
Jun 6, 2018·Journal of the Association for Research in Otolaryngology : JARO·Jennifer S StoneBrandon C Cox
Apr 30, 2015·Development·Patrick J AtkinsonAlan G Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.