In vivo proton magnetic resonance spectroscopy of human spinal mass lesions

Journal of Spinal Disorders & Techniques
Young-Gyun KimJong-Ki Kim

Abstract

To observe metabolic differences between spinal tumor and other diseases in human spinal mass lesions, in vivo 1H magnetic resonance spectroscopy (MRS) was attempted to obtain metabolic signals in patients with various spinal mass lesions. 1H nuclear magnetic resonance (NMR) spectra were obtained from 14 patients before surgery using a receive-only surface coil on a 1.5 T clinical magnetic resonance imaging (MRI) unit. MRS findings were compared with the histopathologic results from biopsy. In addition, tumor spectra were compared with the spectra of other benign diseases including disc herniation, which can mimic spinal cord tumor. In vitro 1H-NMR spectra were also collected from perchloric acid extracts of some spinal tumors. Typical water resonance line widths were in the 6- to 10-Hz range, but the metabolic signals observed were sufficiently resolved to be assigned from comparison with the 1H spectra of brain tissue. Choline was detected in all tumor spectra (n = 6) except ependymoma, whereas it was absent in other benign diseases including disc herniation (mimicking spinal cord tumors), dermoid cyst, tuberculosis, and non-multiple sclerosis myelitis. Spectral patterns of meningiomas, schwannomas, metastasis from renal cell...Continue Reading

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Citations

Dec 15, 2012·AJNR. American Journal of Neuroradiology·A HockS S Kollias
Mar 6, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Muhammad M Abd-El-BarrJohn H Chi
Dec 20, 2015·Journal of Neurosurgery. Pediatrics·Rinchen PhuntsokDouglas L Brockmeyer
Apr 19, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anke HenningUlrike Dydak
Oct 16, 2018·The Indian Journal of Radiology & Imaging·Babu Peter SathyanathanRavi Ranganathan

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