In vivo proton spectroscopy of giant cell tumor of the bone

AJR. American Journal of Roentgenology
Panna Lal SahN R Jagannathan

Abstract

The proton MR spectroscopic finding of elevated choline has been reported to be useful in the differentiation of malignant from benign musculoskeletal tumors. This study was designed to evaluate the MR spectroscopy features of giant cell tumor (GCT) of the bone, primarily to determine whether the presence of choline is a frequent occurrence in these tumors and whether MR spectroscopy features can be correlated with clinical, radiologic, and histopathologic findings. MRI, dynamic contrast-enhanced MRI, and proton MR spectroscopy were performed in 33 patients with bone tumors on a 1.5-T MR scanner. Of these, 12 patients who had GCT of the bone form the subject material for this study. Dynamic contrast-enhanced MRI and single-voxel proton MR spectroscopy were performed after preliminary evaluation with radiography. Patients were divided into two groups, those with elevated choline levels and those without a choline peak on MR spectroscopy. The clinical and radiologic features, including the Campanacci stage and dynamic MRI findings, were compared in these two groups. Core biopsy was performed in all patients, and in 10 of 12 patients, histopathologic evaluation of the postoperative resected specimen was also performed. Although al...Continue Reading

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Citations

Dec 24, 2009·AJR. American Journal of Roentgenology·Laura M FayadPeter B Barker
Jun 23, 2010·AJR. American Journal of Roentgenology·Laura M FayadDavid A Bluemke
Jun 6, 2012·TheScientificWorldJournal·Gandikota GirishDavid Jamadar
Jul 10, 2014·Insights Into Imaging·Duarte NascimentoArmando de Abreu
Oct 26, 2011·Radiologic Clinics of North America·Flávia Martins CostaEmerson Gasparetto
Apr 14, 2009·Radiologic Clinics of North America·Sinchun Hwang, David M Panicek
Dec 16, 2011·European Journal of Radiology·Jing ZhangXiaoguang Cheng
Aug 9, 2011·Journal de radiologie·A El HaddadA Hanine
Dec 24, 2011·AJR. American Journal of Roentgenology·Ty K SubhawongLaura M Fayad
Feb 1, 2019·Journal of Magnetic Resonance Imaging : JMRI·Takeshi FukudaMark E Schweitzer
Sep 30, 2020·Seminars in Musculoskeletal Radiology·B Matthew HoweDoris E Wenger

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