In vivo qualitative analysis of the biocompatibility of different cyanoacrylate-based adhesives

Brazilian Oral Research
Rafael Tobias Moretti NetoAlessandro Antônio Costa Pereira

Abstract

Cyanocrylates have been widely used in the medical and dental fields for several years. In Dentistry, cyanoacrylates have been used for suturing, pulp capping, as retrofilling material in endodontic surgeries, and as cervical plug for pulpless teeth bleaching. The biocompatibility of these adhesives has been the topic of many researches and subcutaneous implantation is an effective methodology for these studies. The present study evaluated the biocompatibility of three different cyanoacrylate-based adhesives. Thirty-six Wistar rats were used, divided into four groups of 9 animals each: A (control)--distilled water, B--cyanoacrylate ester (Super Bonder), C - n-butyl-cyanoacrylate (Histoacryl) and D--alpha-cyanoacrylate (Three Bond). The materials were dispensed in sponges of polyvinyl chloride, the animals were incised and the sponges were inserted in the subcutaneous tissue and sutured. Each group was sub-divided according to the time of sacrifice of the animals: 7, 21 and 45 days. Subjective analysis of the histologic material showed that all groups presented some degree of irritability, but the inflammatory reaction decreased with the experimental time in all groups. Group D showed an inflammatory reaction which was closer to...Continue Reading

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Citations

Nov 8, 2012·Wilderness & Environmental Medicine·Kyle P Davis, Robert W Derlet
May 17, 2011·Acta Biomaterialia·Boaz MizrahiDaniel S Kohane
Jun 3, 2011·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Mayra CardosoDaniel de Moraes Telles
Nov 1, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Etyene Castro DipMauro Granjeiro
Oct 19, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yujia ZhouXiaoyong Wang
Nov 7, 2009·Brazilian Oral Research·Ricardo Carneiro BorraPriscila Maria Andrade
Nov 6, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Niro Kasahara
Apr 23, 2019·BioMed Research International·Eduardo BorieBenjamin Weber
Sep 2, 2015·The Journal of Contemporary Dental Practice·Maria Lúcia Rubo de RezendeMariana S R Zangrando
Nov 18, 2021·Biomaterials Science·Anjeza PetersenMark W Grinstaff

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