In vivo quantification of glucose uptake and conversion to glycogen in individual muscles of the rat following exercise

Metabolism: Clinical and Experimental
S M FurlerE W Kraegen

Abstract

Glycogen depletion is thought to be a potent stimulus for the substantially increased glucose fluxes observed in skeletal muscle following exercise. The aim of this study was to establish the relationships between the glycogen mass and the rates of glucose uptake (Rg') and glucose incorporation into glycogen (Rgly) in individual muscles of conscious adult Wistar rats following moderate nonexhausting treadmill exercise (15 m/min at a 10 degree slope for 45 minutes, approximately 65% VO2max). Muscle glycogen content was determined at 0, 20, 45, 90, or 135 minutes following exercise and compared with Rg' and Rgly measurements at matched times. Muscle types varied in the rate of glycogen resynthesis. Glycogen depots of glycolytic muscle (white gastrocnemius) were still significantly (P < .01) lower than preexercise levels after 135 minutes; red oxidative muscles (soleus and red gastrocnemius) were essentially repleted by 90 minutes. Immediately following exercise, Rg' and Rgly in red gastrocnemius and soleus were 42 +/- 4 and 42 +/- 5 and 36 +/- 2 and 33 +/- 7 micromol/(min . 100 g), greater than the rates induced by maximal insulin stimulation in previous studies. In red muscles, there was a strong inverse relationship between Rgl...Continue Reading

References

Jun 1, 1992·The Journal of Clinical Investigation·P NuutilaU Wegelius
Mar 1, 1991·The Journal of Physiology·J BangsboB Saltin
Apr 1, 1988·Journal of Applied Physiology·J L Johnson, G J Bagby
Jul 1, 1988·The Journal of Clinical Investigation·A B JenkinsE W Kraegen
Jul 1, 1986·Journal of Applied Physiology·P O AstrandG Reynolds
Nov 1, 1985·Journal of Applied Physiology·B Sonne, H Galbo
Jan 1, 1974·Pflügers Archiv : European journal of physiology·R B ArmstrongP D Gollnick
Jun 1, 1973·Journal of Applied Physiology·J WahrenG Ahlborg
Jun 1, 1974·The American Journal of Physiology·R L TerjungJ O Holloszy
Oct 1, 1967·Acta Physiologica Scandinavica·L HermansenB Saltin
Nov 1, 1983·The Journal of Clinical Investigation·C BogardusS Azhar
Feb 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A BrooksT P White
Apr 1, 1982·The Journal of Clinical Investigation·E A RichterN B Ruderman
Feb 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R D FellJ O Holloszy
Oct 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Gaesser, G A Brooks
Feb 1, 1997·Journal of Applied Physiology·A NakataniJ O Holloszy

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Citations

Aug 4, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mary C SugdenMark J Holness
Jun 7, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Karen L SweazeaEldon J Braun
Dec 12, 2017·Journal of Nutritional Science and Vitaminology·Yumiko TakahashiHideo Hatta
May 6, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Yumiko TakahashiHideo Hatta

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