In vivo quantification of myelin changes in the vertebrate nervous system.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yanming WangRobert H Miller

Abstract

Destruction or changes associated with myelin membranes in the CNS play a key role in the pathogenesis of multiple sclerosis and other related neurodegenerative disorders. A long-standing goal has been to detect and quantify myelin content in vivo. For this reason, we have developed a myelin-imaging technique based on positron emission tomography (PET). PET is a quantitative imaging modality that has been widely used in clinical settings for direct assessment of biological processes at the molecular level. However, lack of myelin-imaging probes has hampered the use of PET for imaging of myelination in the CNS. Here, we report a myelin-imaging agent, termed Case Imaging Compound (CIC) that readily penetrates the blood-brain barrier and preferentially localizes to myelinated regions of the brain. After radiolabeling with positron-emitting carbon-11, [(11)C]CIC-PET was conducted in longitudinal studies using a lysolethicin-induced rat model of focal demyelination and subsequent remyelination. Quantitative analysis showed that the retention of [(11)C]CIC correlates with the level of demyelination/remyelination. These studies indicate that, for the first time, [(11)C]CIC-PET can be used as an imaging marker of myelination, which has...Continue Reading

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Citations

Mar 12, 2011·Journal of Medicinal Chemistry·Changning WangYanming Wang
Nov 22, 2011·Journal of Medicinal Chemistry·Luca FrullanoYanming Wang
Jul 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L KiferleP Piccini
Jul 22, 2010·Disease Models & Mechanisms·Robert H Miller, Sharyl L Fyffe-Maricich
Apr 1, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Changning WangYanming Wang
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Changning WangYanming Wang
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