In Vivo Quantitative Photoacoustic Diagnosis of Gastric and Intestinal Dysfunctions with a Broad pH-Responsive Sensor

ACS Nano
Wenchao HuangLiming Nie

Abstract

Gastrointestinal diseases affect many people in the world and significantly impair life quality and burden the healthcare system. The functional parameters of the gastrointestinal tract such as motility and pH can effectively reflect the changes of gastrointestinal activity in physiological and pathological conditions. Thus, a noninvasive method for real-time and quantitative measurement of gastrointestinal functional parameters in vivo is highly desired. At present, there are many strategies widely used for the diagnosis of gastrointestinal diseases in clinic, including X-ray barium meal examination, ultrasound imaging, radionuclide examination, endoscopy, etc. However, these methods are limited in determining the gastrointestinal status and cannot provide comprehensive quantitative information. Photoacoustic imaging (PAI) is a rapid noninvasive real-time imaging technique in which multiple types of functional and quantitative information can be simultaneously obtained. Unfortunately, very few ratiometric PAI contrast agents have been reported for quantification of gastrointestinal functional parameters in vivo. In this work, a broad, pH-responsive ratiometric sensor based on polyaniline and Au triangular nanoplates was develo...Continue Reading

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Citations

Apr 3, 2020·Optics Letters·Wuyu ZhangSihua Yang
Oct 6, 2020·Biomedical Optics Express·Joel W Y TanXueding Wang
Feb 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pengrui ZhuangShao-Kai Sun
Mar 17, 2021·Advanced Biology·Tiancong Ma, Tian Xia
Mar 25, 2021·ACS Applied Materials & Interfaces·Wonjun YimJesse V Jokerst
Jun 24, 2021·Biomaterials Science·Hajra ZafarQi Shen
Jun 19, 2021·Frontiers in Pharmacology·Chun-Ping LiuHong-Xing Liu
Aug 19, 2020·ACS Applied Materials & Interfaces·Jun-Young ParkDongwoo Khang

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