In Vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides

Phytotherapy Research : PTR
Hae June LeeSung Ho Kim

Abstract

This study evaluated the effect of water extracts of Panax ginseng C.A. Meyer (PG), panaxadiol (PD), panaxatriol (PT), ginsenoside Rb(1), Rb(2), Rc, Rd, Re and Rg(1) on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells in gamma-irradiated mice. Jejunal crypts were protected by pretreatment with PG, Rc and Rd. Administration of PG, PD, Rd and Re prior to irradiation resulted in an increase in the formation of endogenous spleen colonies. The frequency of radiation-induced apoptosis in intestinal crypt cells was also reduced by pretreatment with PG, PD, Rb(2), Rc, Rd, Re and Rg(1). In experiments on the effects of the individual ginsenosides, the rank order of activity was Rc > Rd > Rg(1) > Rb(2) > Re > Rb(1) on intestinal crypt survival assay, Re > Rb(2) > Rd > Rg(1) > Rb(1) > Rc on the spleen colony formation assay, and Rg(1) > Re > Rd > Rc > Rb(2) > Rb(1) on inhibiting the death of cells caused by apoptosis. The results indicated that Rc, Rd and Re may have a major radioprotective effect in mice irradiated with high and low doses of radiation. When the same experiments were performed using PD and PT, it was observed that most of the inhibitory effects came from PD rather than PT.

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Citations

May 25, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Tung-Kwang LeeRon R Allison
Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·David D KittsChun Hu
Dec 5, 2009·Phytotherapy Research : PTR·Changjong MoonTaekyun Shin
Feb 27, 2007·Journal of Veterinary Science·Hyun Ji KimHong Gu Joo
Oct 15, 2019·Nutrition and Cancer·Milad AshrafizadehSaeed Samarghandian
Jul 22, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Taiji TamuraMakoto Akashi

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