In vivo radioprotective effects of oltipraz in gamma-irradiated mice

Biochemical Pharmacology
S G KimC W Kim

Abstract

Previous studies in this laboratory have shown that oltipraz (Olt), a chemopreventive agent, enhances radiation(Rad)-inducible glutathione S-transferase (GST) and microsomal epoxide hydrolase (mEH) expression in the liver. The present study was designed to investigate the in vivo radioprotective effect of Olt in ICR mice exposed to a lethal dose of Rad. The 30-day survival rate of mice irradiated at the dose of 8 Gy was substantially increased to 91% by Olt pretreatment (100 mg/kg/day for 2 days), compared with 48% in animals irradiated alone. Light microscopic examinations revealed that exposure of mice to 8 Gy of gamma-ray Rad resulted in hepatocyte degeneration in the surviving animals from Day 1 through Day 22 after irradiation with certain degrees of necrosis observed at early times, whereas Olt treatment provided protection of the liver against irradiation with no hepatic necrosis noted. Mice irradiated at the dose of 8 Gy exhibited time-related decreases in the white blood cell (WBC), red blood cell (RBC), and platelet counts with maximal reduction noted at Day 10. Animals irradiated with Olt treatment showed no difference in peripheral blood cell counts or in the ratio of myeloid to erythroid bone marrow cells, compared...Continue Reading

References

Jan 1, 1990·Annales de chirurgie de la main et du membre supérieur : organe officiel des sociétés de chirurgie de la main = Annals of hand and upper limb surgery·R Tubiana
Apr 1, 1990·International Journal of Radiation Biology·J F WeissE P Clark
Jun 1, 1990·Archives of Biochemistry and Biophysics·P A BellC B Kasper

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Citations

May 7, 1999·Archives of Pharmacal Research·N D Kim, S G Kim
Sep 18, 2012·Journal of Radiation Research·Chengjie ChenChangquan Ling
Apr 24, 2010·The Oncologist·Deborah CitrinJames B Mitchell
Oct 16, 2007·Drug Discovery Today·Seyed Jalal Hosseinimehr
Mar 16, 2005·Chemico-biological Interactions·Sung Hwan KiSang Geon Kim
Oct 16, 2014·Expert Opinion on Therapeutic Patents·Vijay K SinghThomas M Seed
Jul 4, 2012·European Journal of Pharmacology·Janakiraman ShanthakumarNagarajan Rajendra Prasad
Apr 23, 2019·Expert Opinion on Drug Discovery·Vijay K SinghAyodele O Olabisi
Jan 6, 2010·Cancer Research·Akinori MoritaMasahiko Ikekita

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