In vivo regeneration of red cell 2,3-diphosphoglycerate following transfusion of DPG-depleted AS-1, AS-3 and CPDA-1 red cells

British Journal of Haematology
A HeatonS Holme

Abstract

Regeneration of 2,3-diphosphoglycerate (DPG) was determined following transfusion of DPG-depleted group O red cells into group A recipients. Blood from five donors was stored in the adenine-containing solutions CPDA-1, AS-1 or AS-3 for 35 d at 4 degrees C. Post-transfusion red cell DPG and ATP were measured in separated group O red cells over a 7 d period. The studies confirmed rapid in vivo DPG regeneration with greater than or equal to 50% of the maximum level being achieved within 7 h. An average of 95% of the recipients' pre-transfusion DPG level was achieved by 72 h and by 7 d mean (+/- SEM) DPG levels relative to recipient's pre-transfusion DPG averaged 84% (+/- 13%), 92% (+/- 17%) and 84% (+/- 21%) for CPDA-1, AS-1 and AS-3 red cells, respectively. Results were comparable to those previously reported for blood stored in ACD for 15-20 d (Valeri & Hirsch, 1969; Beutler & Wood, 1969). The immediate regeneration rate, V, closely approximated first order regeneration kinetics with AS-3 red cells exhibiting double the rate of CPDA-1 red cells (P less than 0.001). AS-1 red cells exhibited an intermediate rate of regeneration which was not significantly different compared to either CPDA-1 or AS-3 (P greater than 0.05). V exhibit...Continue Reading

References

Feb 1, 1969·The Journal of Pediatrics·D R MillerL W Young
Jul 23, 1970·The New England Journal of Medicine·J TorranceC A Finch
Jul 1, 1984·British Journal of Haematology·A HeatonD H Buchholz
Apr 1, 1965·The Journal of Clinical Investigation·Y SUGITA, E R SIMON
Nov 1, 1950·American Journal of Clinical Pathology·G BRECHER, M SCHNEIDERMAN

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Citations

Sep 6, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ulla Martinsson, Staffan Lundström
Mar 24, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hagop Bessos, Jerard Seghatchian
Feb 14, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Banu AyhanUlku Aypar
Oct 15, 2003·Blood Reviews·S A McLellanT S Walsh
Aug 15, 2001·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·R Jain, C Jarosz
May 1, 1997·Critical Care Medicine·P Van der Linden, J L Vincent
Oct 11, 2005·Critical Care Medicine·Ezz el din S IbrahimTimothy S Walsh
Jul 18, 2008·Critical Care Medicine·Jeremy G PerkinsCharles E Bolan
Oct 6, 1997·Acta Anaesthesiologica Scandinavica·H SchmidtE Jensen
Aug 15, 1998·Vox Sanguinis·C F Högman
Jan 1, 2012·Journal of Blood Transfusion·Mariia ZhurovaJason Acker
Jan 28, 2012·American Journal of Respiratory and Critical Care Medicine·Shailaja J HaydenErik R Swenson
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Andreas H Kramer, David A Zygun
Apr 1, 2014·British Journal of Anaesthesia·S E WrightJ P Wallis
Mar 2, 2013·Anesthesia and Analgesia·Steven M FrankViachaslau M Barodka
Apr 5, 2011·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J Lacroix, M Tucci
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Emre Almac, Can Ince
Nov 17, 2006·British Journal of Haematology·UNKNOWN British Committee for Standards in HaematologyP J Hamilton
Jan 15, 2009·Transfusion Medicine·G J C G M BosmanV M J Novotný
Aug 27, 2015·American Journal of Veterinary Research·Jorge A FontesAndre F Palmer
Oct 24, 2007·Arquivos de neuro-psiquiatria·Rayne Borges TorresVenâncio Pereira Dantas Filho
Jun 25, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Stein Holme
Jul 17, 2018·Biopreservation and Biobanking·Luciana Da Silveira CavalcanteJelena L Holovati
Sep 13, 2006·Transfusion·Claes F HögmanHarold T Meryman
Nov 2, 2006·Transfusion·Alan TinmouthUNKNOWN Canadian Critical Care Trials Group
Feb 1, 2007·Anesthesiology·Hans JutziAlain Borgeat

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