In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens

Journal of Neurochemistry
Jouni A Ihalainen, Heikki Tanila

Abstract

The present study investigated the role of alpha2A-adrenoceptor (alpha2A-AR) subtype in the regulation of noradrenaline (NA) and dopamine (DA) release in the nucleus accumbens (NAc). The effect of locally infused and systemically injected alpha2-AR agonist, dexmedetomidine (DMT), and alpha2-AR antagonist, atipamezole, on NA and DA release was investigated in alpha2A-AR knockout and control mice by using in vivo microdialysis. In addition, we compared the drug effects on DA and NA release in the NAc to their effect on locomotor activity. Baseline NA and DA concentrations did not differ between genotypes. Local infusion of DMT decreased, in a concentration-dependent manner, NA, but not DA, levels in the control mice. However, systemic injection of DMT decreased both NA and DA levels in the control mice. In both cases DMT had no effects on transmitter release in alpha2A-AR knockout mice. Our results suggest that alpha2-ARs regulate the release of NA, but not DA, at the terminal level in the NAc. However, alpha2-ARs regulate DA release in the NAc indirectly by their effect on DA neurones in the ventral tegmental area via an unknown mechanism. In both cases the regulation is mediated by alpha2A-adrenoceptor subtype. Also the modulat...Continue Reading

References

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Citations

Apr 29, 2008·Journal of Child and Adolescent Psychopharmacology·Mihir S ParikhEric Hollander
Mar 7, 2009·Psychopharmacology·Inge E M de JongE Ronald de Kloet
May 11, 2010·Neurochemistry International·Liang PengMeixia Zhang
Jan 16, 2010·The European Journal of Neuroscience·Ana F CarvalhoElisabeth J Van Bockstaele
Mar 20, 2010·Journal of Neurochemistry·Masato HaraAkinori Nishi
Oct 14, 2014·Frontiers in Cellular Neuroscience·Francisca MeyerMichel M M Verheij
Mar 15, 2006·Current Opinion in Anaesthesiology·Andrea Paris, Peter H Tonner
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiKevin D Lominac
Jan 24, 2006·Anesthesia and Analgesia·Robert A Whittington, László Virág
Mar 2, 2006·European Journal of Anaesthesiology·R Aantaa, J Jalonen
Oct 27, 2011·Pharmazie in unserer Zeit·Peter H Tonner, Andrea Paris
Feb 22, 2012·The Journal of Pharmacology and Experimental Therapeutics·Heramb ChadchankarLeonid Yavich
Mar 20, 2018·Molecular Neurobiology·Marta Sánchez-SotoSergi Ferré

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