PMID: 9423840Jan 10, 1998Paper

In vivo regulation of replicative Legionella pneumophila lung infection by endogenous interleukin-12

Infection and Immunity
J K BrielandJ C Fantone

Abstract

The in vivo role of endogenous interleukin 12 (IL-12) in modulating intrapulmonary growth of Legionella pneumophila was assessed by using a murine model of replicative L. pneumophila lung infection. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L. pneumophila cells per mouse) resulted in induction of IL-12, which preceded clearance of the bacteria from the lung. Inhibition of endogenous IL-12 activity, via administration of IL-12 neutralizing antiserum, resulted in enhanced intrapulmonary growth of the bacteria within 5 days postinfection (compared to untreated L. pneumophila-infected mice). Because IL-12 has previously been shown to modulate the expression of cytokines, including gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and IL-10, which regulate L. pneumophila growth, immunomodulatory effects of endogenous IL-12 on intrapulmonary levels of these cytokines during replicative L. pneumophila lung infection were subsequently assessed. Results of these experiments demonstrated that TNF-alpha activity was significantly lower, while protein levels of IFN-gamma and IL-10 in the lung were similar, in L. pneumophila-infected mice administered IL-12 antiserum, compared to similarly infe...Continue Reading

References

Oct 1, 1979·Journal of Clinical Microbiology·J C FeeleyW B Baine
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·U GublerP C Familletti
Feb 1, 1990·Immunological Investigations·M K EskandariD G Remick
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A S SternR Chizzonite
Jun 1, 1983·The Journal of Clinical Investigation·M A Horwitz
Jan 1, 1984·Infection and Immunity·H FriedmanK Cabrian
Sep 1, 1980·The Journal of Clinical Investigation·M A Horwitz, S C Silverstein
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K KobayashiR M Nakamura
Sep 1, 1994·Microbial Pathogenesis·R D WagnerC J Czuprynski
May 1, 1993·The Journal of Experimental Medicine·F P HeinzelM K Gately
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R T GazzinelliA Sher
Nov 1, 1996·Experimental Parasitology·W E Carson, M A Caligiuri
Oct 31, 1996·Annals of the New York Academy of Sciences·X MaG Trinchieri
Apr 1, 1997·The Journal of Infectious Diseases·R AllendoerferG S Deepe

❮ Previous
Next ❯

Citations

Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TatedaT J Standiford
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roman SpörriAnnette Oxenius
Sep 11, 2008·Cellular Microbiology·Kristina A ArcherCraig R Roy
Dec 3, 2013·World Journal of Microbiology & Biotechnology·Abolfazl GholipourSeyyed Ali Mard
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiaki KikuchiToshihiro Nukiwa
Dec 16, 2004·FEMS Microbiology Letters·Jennifer Naylor, Nicholas P Cianciotto
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roman SpörriAnnette Oxenius
Feb 23, 2007·Journal of Medical Microbiology·Etsu T FuseKeizo Yamaguchi
Apr 9, 2010·Clinical Microbiology Reviews·Hayley J NewtonElizabeth L Hartland
Jul 30, 2008·Expert Review of Anti-infective Therapy·April Kaur Randhawa, Thomas R Hawn
Apr 29, 2009·Infection and Immunity·Kimberly A AllardNicholas P Cianciotto
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J TodtJ L Curtis
Jan 8, 2017·Archives of Pharmacal Research·Bonggoo ParkKyung-Mi Lee
Feb 17, 2001·Infection and Immunity·K MatsunagaY Yamamoto
Oct 8, 2004·Cellular Microbiology·Annie L Neild, Craig R Roy
Dec 17, 2008·Mucosal Immunology·E L WissingerT Hussell
Mar 9, 2011·Infection and Immunity·Kessler McCoy-SimandleNicholas P Cianciotto
Jul 25, 2007·Infection and Immunity·David K R KaraolisTheodore J Standiford
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane C DengTheodore J Standiford
Nov 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Stephanie R ShamesCraig R Roy
Feb 23, 2021·Frontiers in Cellular and Infection Microbiology·Tshegofatso NgwagaStephanie R Shames
Jul 29, 2019·Journal of Molecular Biology·Xin Liu, Sunny Shin
Sep 10, 2017·World Journal of Microbiology & Biotechnology·Ashraf Mohabati MobarezAli Hatef Salmanian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.