PMID: 9188767Jan 1, 1997Paper

In vivo regulation of serotonin 5-HT2A receptors in rat brain by subchronic administration of sigma receptor ligand NE-100

Life Sciences
K HashimotoY Minabe

Abstract

In the present study, we examined the effect of the novel sigma receptor ligand NE-100 on 5-hydroxytryptamine-2A (5-HT2A) receptor binding in rat brain using an in vivo approach. Rats received intraperitoneal injections of either vehicle (1 ml/kg) or NE-100 (3 mg/kg) twice daily for 14 days. The in vivo binding of [3H]RP 62203, a selective 5-HT2A receptor radioligand, to 5-HT2A receptors in the rat brain was examined at 1, 3 or 7 days after final treatment. The specific binding of [3H]RP 62203 in the frontal cortex, parietal cortex and occipital cortex 1 day after subchronic administration of NE-100 was significantly increased as compared to animals treated with vehicle. In contrast, specific binding in the frontal cortex and parietal cortex 3 days after subchronic administration of NE-100 was significantly decreased as compared with the vehicle treated group. Seven days after the last injection of NE-100 or vehicle, there were no significant differences between the NE-100 and vehicle treated groups in [3H]RP 62203 binding in all the regions examined except for the hippocampus. These findings indicate that subchronic treatment with NE-100 may regulate the in vivo binding characteristics of 5-HT2A receptors in the cerebral corte...Continue Reading

References

Oct 1, 1992·Neurochemical Research·H ShibuyaM Toru
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S W Tam, L Cook
Jan 4, 1996·The New England Journal of Medicine·J M Kane
Feb 1, 1995·Schizophrenia Research·A Breier
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M HannerH Glossmann
Mar 1, 1996·Psychopharmacology·B J Kinon, J A Lieberman

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Citations

Sep 6, 2005·Biological Psychiatry·Nicole SchmitzDeclan G M Murphy
Jul 27, 2021·Frontiers in Physiology·Richa AishwaryaMd Shenuarin Bhuiyan

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