In vivo remodeling potential of a novel bioprosthetic tricuspid valve in an ovine model

The Journal of Thoracic and Cardiovascular Surgery
Anna M FallonRobert G Matheny

Abstract

A novel bioprosthetic tricuspid valve was constructed from an acellular extracellular matrix (ECM) bioscaffold. The valve's mechanical functionality and potential for histologic regeneration was evaluated in an ovine model. The native tricuspid valves of 4 domestic sheep were excised and replaced with bioprosthetic valves constructed from the ECM bioscaffold material shaped into the form of a tube. In vivo function was assessed over time by transthoracic echocardiography. Animals were euthanized at 3, 5, 8, and 12 months after valve implantation, and explanted valves were examined for gross morphology and by qualitative histopathologic analysis. All 4 sheep survived until the specified date. Forward flow by echocardiography was normal with trivial to mild regurgitation. Annular morphology and mobility of the leaflets appeared normal with excellent leaflet coaptation. Explanted valves were grossly normal at all time points and showed evidence of progressive tissue remodeling and integration at the host-tissue interface. Histopathologic analysis demonstrated massive host-cell infiltration, structural reorganization of the ECM bioscaffold, elastin generation at the annulus by 3 months, and increased collagen organization and glyco...Continue Reading

References

Nov 7, 1998·The Journal of Thoracic and Cardiovascular Surgery·M C Robotin-JohnsonJ L Cox
Aug 15, 2000·Tissue Engineering·T B McPhersonS F Badylak
May 26, 2004·Transplant Immunology·Stephen F Badylak
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·James L CoxR C Quijano
May 2, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thore ZantopStephen F Badylak
Dec 18, 2007·Seminars in Immunology·Stephen F Badylak, Thomas W Gilbert
Jul 26, 2008·Tissue Engineering. Part a·Janet E ReingStephen F Badylak
Oct 8, 2008·Tissue Engineering. Part a·Allison J BeattieStephen F Badylak
Oct 22, 2008·Acta Biomaterialia·Stephen F BadylakThomas W Gilbert
Oct 28, 2008·Tissue Engineering. Part a·Stephen F BadylakAnn M Stewart-Akers
Jan 8, 2009·Tissue Engineering. Part a·Jolene E ValentinStephen F Badylak
May 6, 2009·Annual Review of Biomedical Engineering·Michael S SacksJohn E Mayer
Aug 25, 2009·Journal of Tissue Engineering and Regenerative Medicine·Vineet AgrawalStephen F Badylak
Feb 2, 2011·Advanced Drug Delivery Reviews·Jonathan T ButcherLaura A Hockaday
Feb 15, 2011·Current Opinion in Biotechnology·Frederick J Schoen

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Citations

May 21, 2014·The Journal of Thoracic and Cardiovascular Surgery·Yoshiya ToyodaAkira Shiose
Oct 12, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Alvise GuarientoMassimo Padalino
Jun 13, 2014·Echocardiography·Clifford L CuaPatrick I McConnell
Sep 2, 2014·The Journal of Thoracic and Cardiovascular Surgery·Marc W GerdischVivek Rao
Dec 24, 2014·Journal of Cardiac Surgery·Tomas HolubecFrancesco Maisano
Jun 9, 2015·The Journal of Thoracic and Cardiovascular Surgery·Naohiko NemotoRobert S Schwartz
Feb 26, 2016·Interactive Cardiovascular and Thoracic Surgery·Zahra Mosala NezhadGebrine El Khoury
Sep 24, 2016·Interactive Cardiovascular and Thoracic Surgery·Zahra Mosala NezhadPierre Gianello
Apr 14, 2016·Advanced Healthcare Materials·Jeremy J Glynn, Monica T Hinds
Oct 20, 2017·Interactive Cardiovascular and Thoracic Surgery·Olga N KislitsinaJames L Cox
Sep 25, 2017·Echocardiography·Clifford L CuaPatrick I McConnell
Feb 11, 2020·Journal of Cardiovascular Translational Research·Garrett N CoyanAntonio D'Amore
Feb 19, 2020·Pacing and Clinical Electrophysiology : PACE·M Rizwan SohailJohn N Catanzaro
Aug 5, 2014·Current Opinion in Pediatrics·Robert B Hinton
Mar 16, 2017·Cold Spring Harbor Perspectives in Medicine·Ekene OnwukaChristopher Breuer
Oct 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jeremy J GlynnMonica T Hinds
Dec 21, 2016·Cardiovascular Engineering and Technology·Sharan RamaswamyFrank Scholl
Dec 6, 2019·Tissue Engineering. Part a·Brittany A GonzalezSharan Ramaswamy
Sep 11, 2020·Nature Reviews. Cardiology·Emanuela S FiorettaMaximilian Y Emmert
Nov 24, 2020·Journal of Cardiac Surgery·Daniel Buitrago, Leonardo Mulinari
Jun 4, 2021·Acta Biomaterialia·Marcus GroundJillian Cornish

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