PMID: 9192641Jun 24, 1997Paper

In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus

Proceedings of the National Academy of Sciences of the United States of America
Mervin C YoderP Mukherjee

Abstract

The murine yolk sac, being the first site of embryonic blood cell production, has long been theorized to contain the migrating hematopoietic stem cells (HSC) that seed the liver and initiate hematopoiesis on day 10.0 postcoitus (pc). However, it remains controversial whether yolk sac cells isolated before day 11.0 pc possess any long-term repopulating HSC activity upon transplantation into adult recipient mice. We hypothesized that failure to demonstrate engraftment of day <11.0 yolk sac cells in adult hosts may result from an inability of yolk sac cells to home to the active adult hematopoietic sites (spleen and bone marrow). In the present studies, we transplanted yolk sac cells into conditioned newborn mice in whom the liver, as well as the spleen and bone marrow, concomitantly function as a site of blood cell formation. We report that yolk sac cells isolated from day 9.0 pc embryos provide long-term multilineage reconstitution for at least 11 months in primary conditioned newborn mice and for at least 6 months in secondary recipients. Donor yolk sac HSC progeny repopulated mature peripheral blood, thymus, spleen, and bone marrow lymphoid, myeloid, and erythroid compartments. Thus, day 9.0 pc yolk sac HSC can contribute to d...Continue Reading

References

Sep 19, 1979·The Journal of Experimental Medicine·C J PaigeG Lee
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·I L WeissmanW Raschke
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J F TolesJ E Barker
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C A CudennecN M Le Douarin
Sep 1, 1995·Trends in Genetics : TIG·E Dzierzak, A Medvinsky
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·I GodinA Cumano
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R Palacios, B A Imhof
Jan 1, 1996·Immunity·S Delassus, A Cumano

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Citations

Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L Robb, A G Elefanty
Oct 31, 2003·Experimental Hematology·Michael Kyba, George Q Daley
Dec 10, 2003·Experimental Hematology·Margaret H Baron
Aug 13, 1998·Developmental and Comparative Immunology·J A Garcia-PorreroI E Godin
Jul 6, 2000·Experimental Hematology·A M Lichanska, D A Hume
Aug 10, 2001·Experimental Hematology·J Palis, M C Yoder
May 26, 1999·Experimental Hematology·J ChenD E Harrison
Nov 16, 2013·Experimental & Molecular Medicine·Michael R Copley, Connie J Eaves
Jun 8, 2011·Leukemia·K V PajciniW S Pear
Feb 24, 2007·Nature Reviews. Immunology·Kenneth Dorshkind, Encarnacion Montecino-Rodriguez
Apr 27, 2013·Nature Reviews. Immunology·Wilson K Clements, David Traver
Apr 12, 2001·British Journal of Haematology·C J Marshall, A J Thrasher
Apr 16, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Naoki KimuraTetsuya Taga
Oct 24, 2001·Journal of Hematotherapy & Stem Cell Research·M H Baron
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Hanna K A Mikkola, Stuart H Orkin
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Kyunghee Choi
Jun 7, 2006·Current Opinion in Hematology·Christa E Muller-Sieburg, Hans B Sieburg
Jun 6, 2009·Current Opinion in Hematology·Julien Y Bertrand, David Traver
Jun 18, 1999·Annals of the New York Academy of Sciences·D D Cooper, G J Spangrude
Mar 5, 2003·Annual Review of Immunology·Motonari KondoIrving L Weissman
Jan 22, 2005·Annual Review of Medicine·Judith A ShizuruIrving L Weissman
Feb 7, 2012·Blood·Anna Bigas, Lluis Espinosa
Dec 8, 2010·Critical Reviews in Eukaryotic Gene Expression·Yiting Lim, William Matsui
Dec 25, 2003·Archives of Histology and Cytology·Nagwa El-NefiawyToshihiko Terao
May 28, 2013·Cellular and Molecular Life Sciences : CMLS·Igor M Samokhvalov
Jan 15, 2014·Stem Cells and Development·Yang LinMomoko Yoshimoto
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShinoharaR L Brinster
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·J PalisM C Yoder
Aug 21, 2013·Blood Cells, Molecules & Diseases·Victoria MoignardBerthold Göttgens
Nov 30, 2011·TheScientificWorldJournal·Daisuke SugiyamaYuka Horio

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