In vivo reprogramming for heart regeneration: A glance at efficiency, environmental impacts, challenges and future directions

Journal of Molecular and Cellular Cardiology
Behnam Ebrahimi

Abstract

Replacing dying or diseased cells of a tissue with new ones that are converted from patient's own cells is an attractive strategy in regenerative medicine. In vivo reprogramming is a novel strategy that can circumvent the hurdles of autologous/allogeneic cell injection therapies. Interestingly, studies have demonstrated that direct injection of cardiac transcription factors or specific miRNAs into the infarct border zone of murine hearts following myocardial infarction converts resident cardiac fibroblasts into functional cardiomyocytes. Moreover, in vivo cardiac reprogramming not only drives cardiac tissue regeneration, but also improves cardiac function and survival rate after myocardial infarction. Thanks to the influence of cardiac microenvironment and the same developmental origin, cardiac fibroblasts seem to be more amenable to reprogramming toward cardiomyocyte fate than other cell sources (e.g. skin fibroblasts). Thus, reprogramming of cardiac fibroblasts to functional induced cardiomyocytes in the cardiac environment holds great promises for induced regeneration and potential clinical purposes. Application of small molecules in future studies may represent a major advancement in this arena and pharmacological reprogram...Continue Reading

Citations

Feb 21, 2018·Acta Biochimica Et Biophysica Sinica·Jian WuJian Xu
Jan 30, 2018·Stem Cells International·Fabiana PassaroDomenico Bonaduce
May 15, 2018·Frontiers in Cardiovascular Medicine·Fabiana Passaro, Gianluca Testa
Aug 14, 2018·Science China. Life Sciences·Hua QinXiaobing Fu
Apr 24, 2019·Nature Biomedical Engineering·Haodong ChenJoseph C Wu
Apr 10, 2019·Biomaterials·Brian W WalkerNasim Annabi
Jun 3, 2021·Seminars in Cell & Developmental Biology·James W S JahngJoseph C Wu
Jan 24, 2019·Cell Regeneration·Behnam Ebrahimi

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