In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity

The Journal of Clinical Investigation
P BougnèresD Ricquier

Abstract

A decreased mobilization of triglycerides may contribute to fat accumulation in adipocytes, leading to obesity. However, this hypothesis remains to be proven. In this study, epinephrine-induced lipid mobilization was investigated in vivo in nine markedly obese children (160+/-5% ideal body weight) aged 12.1+/-0.1 yr during the dynamic phase of fat deposition, compared with six age-matched nonobese children. As an in vivo index of lipolysis, we measured glycerol flux using a nonradioactive tracer dilution approach, and plasma free fatty acid concentrations. In the basal state, the obese children had a 30% lower rate of glycerol release per unit fat mass than the lean children. To study the regulation of lipolysis, epinephrine was infused stepwise at fixed doses of 0.75 and then 1. 50 microg/min in both groups. In lean children, glycerol flux and plasma free fatty acid increased to an average of 249-246% of basal values, respectively, in response to a mean plasma epinephrine of 396+/-41 pg/ml. The corresponding increase was only 55-72% in the obese children, although their mean plasma epinephrine reached 606+/-68 pg/ml. All obese and nonobese children, except an Arg64Trp heterozygote, were homozygotes for Trp at position 64 of th...Continue Reading

References

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·P DelamarcheR Favier
Apr 1, 1992·Diabetes·C Le Stunff, P F Bougnères
Aug 26, 1989·Lancet·H O Mossberg
Apr 1, 1989·The Journal of Clinical Investigation·M D JensenJ M Miles
May 1, 1987·American Journal of Diseases of Children·S L GortmakerC A Wehler
Dec 1, 1981·The Journal of Clinical Endocrinology and Metabolism·P ArnerJ Nowak
Jun 1, 1995·Journal of the American College of Cardiology·C C de Jong-de Vos van SteenwijkK H Wesseling
Mar 1, 1995·The Journal of Clinical Investigation·F LönnqvistP Arner
Jun 1, 1994·The Journal of Clinical Investigation·S ReynisdottirP Arner
Aug 11, 1993·Journal of Chromatography·M CanditoP Chambon

❮ Previous
Next ❯

Citations

Sep 26, 2001·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D QuilliotO Ziegler
May 11, 2010·European Journal of Applied Physiology·H ZouhalC Jacob
May 15, 2012·Journal of Inherited Metabolic Disease·W Todd CadeLinda R Peterson
Apr 25, 2013·Sports Medicine·Hassane ZouhalGeorges Jabbour
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M A van Baak
May 13, 2009·The Journal of Biological Chemistry·Véronic BezaireDominique Langin
Oct 30, 1998·The Proceedings of the Nutrition Society·S W CoppackV Mohamed-Ali
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Max Lafontan
Mar 21, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·R LiE Gerlo
Feb 19, 2008·Sports Medicine·Julien AucouturierPascale Duché
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Diane C Adler-WailesJack A Yanovski
Oct 22, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Zhengtang Qi, Shuzhe Ding
May 26, 2009·Progress in Lipid Research·Max Lafontan, Dominique Langin
Sep 23, 2008·Metabolism: Clinical and Experimental·Ilya R Bederman, Stephen F Previs
Feb 12, 2008·Physiology & Behavior·Johan W E Jocken, Ellen E Blaak
May 22, 2007·Metabolism: Clinical and Experimental·John J LimaHardesh Garg
Nov 5, 2004·Diabetes & Metabolism·V LargeM Beylot
Jul 25, 2006·Comptes rendus biologies·Dominique Langin
Apr 4, 2006·Physiology & Behavior·Margriet Westerterp-PlantengaAngelo Tremblay
Jan 12, 2002·Obesity Research·Charles CouillardJean-Pierre Després
Oct 27, 2005·Diabetes·Dominique LanginPeter Arner
Oct 5, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Denis P Blondin, André C Carpentier
Mar 19, 2008·Diabetes Research and Clinical Practice·Yuzuru OhshiroKishio Nanjo
May 11, 2006·Journal of Lipid Research·Christina Koutsari, Michael D Jensen
Feb 12, 2017·The Journal of Clinical Endocrinology and Metabolism·Andrea Di NisioCarlo Foresta
Jun 8, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G Á Martos-MorenoJ Argente
May 19, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E Bobbioni-HarschA Golay
Jun 17, 2006·Diabetes, Obesity & Metabolism·K C R BaynesM G Giannoulis
May 6, 2019·Archives of Physiology and Biochemistry·Bimit MahatPascal Imbeault
Jan 13, 2015·Nature Communications·Shannon M ReillyAlan R Saltiel
Aug 12, 2017·Nature Reviews. Endocrinology·Shannon M Reilly, Alan R Saltiel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.