In vivo respiratory toxicology of cooking oil fumes: Evidence, mechanisms and prevention.

Journal of Hazardous Materials
Yongsheng MaQihong Deng

Abstract

As cooking is an essential part of people's daily life, cooking oil fumes (COF) has been recognized as one of the major indoor air pollutant. Mounting epidemiological evidence has indicated that COF exposure is significantly associated with an increased risk of various health effects including lung cancer, but toxicological studies are very limited. We conduct a systematic study to provide toxicological evidence of COF exposure on the lungs, to examine the underlying toxicological mechanism, and to suggest intervention measures to mitigate this toxicity. A total 96 female rats were randomly divided into control groups, COF exposure groups (0.2, 2, 20 mg/kg) and vitamin E protection groups, receiving appropriate treatment for 30 days. First we measured airway hyperresponsiveness (AHR) followed by a lung histological analysis to investigate the toxicological effects of COF. We next analyzed the biomarkers of oxidative stress, inflammation, and apoptosis to examine the underlying toxicological mechanism, and finally we investigated the protective effects of vitamin E against the toxicity of COF. AHR measurement indicated that the airway resistance increased with the COF dose and the lung histological assay showed narrowing of the ...Continue Reading

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Citations

Jan 30, 2021·BioMed Research International·Ana Elizabeth González-SantiagoMaría Guadalupe Sánchez-Parada
Jul 2, 2021·Ecotoxicology and Environmental Safety·Linjing DengQihong Deng

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