In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.

PLoS Medicine
Michael J SorichWilliam E Evans

Abstract

Childhood acute lymphoblastic leukemia (ALL) is the most common cancer in children, and can now be cured in approximately 80% of patients. Nevertheless, drug resistance is the major cause of treatment failure in children with ALL. The drug methotrexate (MTX), which is widely used to treat many human cancers, is used in essentially all treatment protocols worldwide for newly diagnosed ALL. Although MTX has been extensively studied for many years, relatively little is known about mechanisms of de novo resistance in primary cancer cells, including leukemia cells. This lack of knowledge is due in part to the fact that existing in vitro methods are not sufficiently reliable to permit assessment of MTX resistance in primary ALL cells. Therefore, we measured the in vivo antileukemic effects of MTX and identified genes whose expression differed significantly in patients with a good versus poor response to MTX. We utilized measures of decreased circulating leukemia cells of 293 newly diagnosed children after initial "up-front" in vivo MTX treatment (1 g/m(2)) to elucidate interpatient differences in the antileukemic effects of MTX. To identify genomic determinants of these effects, we performed a genome-wide assessment of gene expressio...Continue Reading

References

Sep 1, 1985·The Journal of Clinical Investigation·B A ChabnerJ Jolivet
Oct 3, 1996·The New England Journal of Medicine·R GorlickJ R Bertino
Sep 18, 1996·Journal of the National Cancer Institute·K W Kohn
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·S RamaswamyT R Golub
Jun 27, 2002·Biochimica Et Biophysica Acta·Debabrata BanerjeeJoseph R Bertino
Mar 6, 2003·British Journal of Cancer·P KaaijkA J P Veerman
Jul 11, 2003·Vitamins and Hormones·Larry H Matherly, David I Goldman
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Aug 15, 2003·The New England Journal of Medicine·Ching-Hon PuiMelissa M Hudson
Sep 16, 2003·Journal of Pediatric Hematology/oncology·Adam S LevyUNKNOWN Children's Cancer Group Study
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Ching-Hon PuiWilliam E Evans
Dec 25, 2003·Bioinformatics·Jelle J GoemanHans C van Houwelingen
Apr 9, 2004·The New England Journal of Medicine·Ching-Hon PuiJames R Downing
May 6, 2004·Annals of Hematology·T HaferlachC Schoch
May 28, 2004·Nature·William E Evans, Mary V Relling
Aug 6, 2004·The New England Journal of Medicine·Amy HollemanWilliam E Evans
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Feb 17, 2005·Blood·Jose Claudio C RochaMary V Relling
Jan 13, 2006·The New England Journal of Medicine·Ching-Hon Pui, William E Evans
Feb 24, 2006·Nature Reviews. Cancer·Meyling H Cheok, William E Evans
Aug 29, 2006·Molecular Pharmacology·Hitoshi UgaHiroshi Handa

❮ Previous
Next ❯

Citations

Nov 10, 2013·Omics : a Journal of Integrative Biology·Brooke L FridleyLiewei Wang
Sep 24, 2010·Current Opinion in Pediatrics·Steven W PaughWilliam E Evans
Feb 15, 2011·Pharmacogenetics and Genomics·Torben S MikkelsenRuss B Altman
Aug 24, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhuang ZuoRajyalakshmi Luthra
Jan 20, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Joanna SzczepanekMariusz Wysocki
Nov 7, 2009·Pharmacogenomics·Christophe Roumier, Meyling H Cheok
Aug 18, 2012·Leukemia & Lymphoma·Vanessa S SilveiraLuiz Gonzaga Tone
Jun 10, 2011·Trends in Molecular Medicine·Jakob Lewin Rukov, Noam Shomron
Dec 23, 2008·Seminars in Hematology·Meyling H CheokWilliam E Evans
Jun 23, 2009·British Journal of Haematology·Kjeld Schmiegelow
May 25, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·John C PanettaWilliam E Evans
Feb 16, 2012·Biomedical Chromatography : BMC·Emi SonemotoKenichiro Nakashima
Aug 22, 2013·Journal of the National Cancer Institute·Wenting WangKevin R Coombes
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ching-Hon PuiCharles G Mullighan
Mar 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Torben S MikkelsenWilliam E Evans
Nov 8, 2008·Journal of Pediatric Hematology/oncology·Marie Louise DavidsenKjeld Schmiegelow
Jan 27, 2011·Zeitschrift für Rheumatologie·H Mühl, J Pfeilschifter
Oct 6, 2012·The Journal of Toxicological Sciences·Sayuri KojimaTakanori Harada
Feb 2, 2019·Current Drug Metabolism·Guillermo Gervasini, Sonia Mota-Zamorano
Jun 18, 2014·Journal of Pediatric Hematology/oncology·Kjeld SchmiegelowJacob Nersting
Mar 6, 2009·Journal of Pediatric Hematology/oncology·Meyling H CheokLeo Kager
Sep 9, 2008·Journal of Pediatric Hematology/oncology·Barton A Kamen
Apr 19, 2017·Oncotarget·Qianqian HouYang Shu
Dec 26, 2019·BMC Bioinformatics·Jianwei LuTianwei Yu
Feb 28, 2016·Annals of the Rheumatic Diseases·Cristina MunicioAmaya Puig-Kröger
Nov 1, 2016·Bioinformatics·Yan YanTianwei Yu
Nov 10, 2020·The Journal of Clinical Investigation·Elixabet Lopez-LopezWilliam E Evans

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE10255

Methods Mentioned

BETA
flow cytometry

Software Mentioned

R Bioconductor
R
ModFit

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis