In vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imaging

NeuroImage
Kevin C ChanEd X Wu

Abstract

The superior colliculus (SC) is a dome-shaped subcortical laminar structure in the mammalian midbrain, whose superficial layers receive visual information from the retina in a topological order. Despite the increasing number of studies investigating retinotopic projection in visual brain development and disorders, in vivo, high-resolution 3D mapping of topographic organization in the subcortical visual nuclei has not yet been available. This study explores the capability of 3D manganese-enhanced MRI (MEMRI) at 200 μm isotropic resolution for in vivo retinotopic mapping of the rat SC upon partial transection of the intraorbital optic nerve. One day after intravitreal Mn(2+) injection into both eyes, animals with partial transection at the right superior intraorbital optic nerve in Group 1 (n=8) exhibited a significantly lower T1-weighted signal intensity in the lateral region of the left SC compared to the left medial SC and right control SC. Partial transection toward the temporal or nasal region of the right intraorbital optic nerve in Group 2 (n=7) led to T1-weighted hypointensity in the rostral or caudal region of the left SC, whereas a clear border was observed separating 2 halves of the left SC in all groups. Previous hist...Continue Reading

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Citations

Jan 8, 2011·Journal of Integrative Neuroscience·Kevin C ChanEd X Wu
Jan 12, 2013·Investigative Ophthalmology & Visual Science·Tsung-Han ChouVittorio Porciatti
Mar 5, 2016·Japanese Journal of Radiology·Jun YangChengde Liao
Dec 1, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Iris Y ZhouEd X Wu
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin C ChanEd X Wu
Jun 18, 2014·NeuroImage·Tsen-Hsuan LinSheng-Kwei Song
Aug 22, 2016·Acta Neuropathologica·Benjamin Michael DavisMaria Francesca Cordeiro
Oct 4, 2017·Oncotarget·Thibaud MathisJuliette Thariat
May 26, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Zuohua TangLixin Jin
Oct 4, 2011·Journal of Magnetic Resonance Imaging : JMRI·Govind NairTimothy Q Duong
Aug 22, 2017·Advanced Functional Materials·Haoyuan Huang, Jonathan F Lovell
Apr 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yolandi van der MerweKevin C Chan

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