In vivo role of glucocorticoids in barotrauma vascular repair and fibrosis

Journal of Molecular and Cellular Cardiology
M A KarimD D Miller

Abstract

To determine the important repair events leading to vascular collagen accumulation following barotrauma, in vivo changes were assessed during dexamethasone (DEX) treatment, as well as physiological healing. Hypercholesterolemic rabbits underwent bilateral iliac artery endothelial denudation, followed by angioplasty. Messenger ribonucleic acid (RNA) (procollagen types I, III and transforming growth factor [TGF]beta1), and bio-histometric composition of iliac arteries of animals treated with DEX (2, 7 and 7 days; 1 mg/kg1/day1), were compared to that in controls 2, 7 and 30 days after angioplasty. Type I and III procollagen mRNA transcripts were up-regulated following injury in either group. Similarly, TGFbeta1 mRNA levels were also elevated; however, treatment with DEX led to down-regulation at day 30 post-angioplasty. Linear regression and correlation of the densitometric ratios of procollagen alpha1(I) and TGFbeta1 mRNA during repair were observed significantly in either group (DEX-treated, r2= 0.84; non-treated, r2=0.79). Biochemically derived total vascular RNA concentration decreased transiently (7 days), with DEX-treatment (P = 0.003). Arterial lumen cross-sectional area was reduced between days 2 and 30 (P=<0.02), accompa...Continue Reading

Citations

Mar 9, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yixin KangHongbo Chang
May 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·P J BrayT A McCaffrey
Feb 26, 2009·British Journal of Pharmacology·Patrick W F HadokeBrian R Walker
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Kazuhiko SuzukiKunio Doi

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