In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark.

Emerging Infectious Diseases
Rasmus K HareM C Arendrup

Abstract

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

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Citations

Jan 16, 2020·Journal of Fungi·Mireille H van der TorreRiina Rautemaa-Richardson
Apr 24, 2020·Drugs·Lu ChenRoger J M Brüggemann
Aug 23, 2020·Journal of Fungi·Amir ArastehfarDavid S Perlin
Sep 12, 2020·Environmental Science and Pollution Research International·Hailemariam Abrha AssressTitus A M Msagati
Mar 15, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Natália Sayuri WassanoAndré Damasio
Aug 21, 2020·International Journal of Environmental Health Research·Carla ViegasRaquel Sabino
Mar 7, 2021·Journal of Fungi·Mireille H van der TorreLilyann Novak-Frazer
May 27, 2021·Studies in Mycology·A ArastehfarM Hoenigl
Dec 10, 2021·PLoS Pathogens·Rafael W BastosDaniel A Santos
Dec 7, 2021·Microbiology and Immunology·Sofia Marisel Rivelli Zea, Takahito Toyotome

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Datasets Mentioned

BETA
MG972983
MG972984

Methods Mentioned

BETA
genotyping
dissection

Software Mentioned

FastTree
NUCmer
NASP

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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