PMID: 9188549Jul 1, 1997Paper

In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression

Journal of Virology
T ShiodaY Nagai

Abstract

According to the rate of depletion of CD4 cell counts, we grouped 12 cases of human immunodeficiency virus type 1 (HIV-1) infection as 6 rapid (21.0 to 33.8 cells per microl per month) and 6 slow (0.9 to 7.9 cells per microl per month) progressors and determined the individual viral quasispecies patterns by sequencing the genome region encoding the V1, V2, and V3 loops of envelope protein. Although the quasispecies structures varied widely from one individual to another, a strong correlation was observed between a low rate of disease progression and a high degree of genetic diversity of HIV-1. Furthermore, the V2 loop extension was observed specifically in individuals with slow or no disease progression, whereas basic amino acid substitutions in V3 characteristic of a viral phenotype shift from non-syncytium inducing to syncytium inducing were observed in patients with advanced stages of disease regardless of their rate of disease progression. Studies with recombinant viruses suggested that elongation of V2 potentially restricts the capacity of HIV-1 to replicate in macrophages. Thus, our results suggest the association of distinct sequence features of both V3 and V2 with particular patterns of disease progression. Elongation o...Continue Reading

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Citations

Aug 9, 2002·AIDS Research and Human Retroviruses·Alexandra M KlevytskaSusan H Eshleman
Aug 19, 2003·The Journal of Biological Chemistry·Pantelis PoumbouriosHeidi E Drummer
Mar 30, 2005·AIDS Research and Human Retroviruses·Xiao-Nan DongYing-Hua Chen
Dec 7, 2006·AIDS Research and Human Retroviruses·Alexander N GalkinTatyana V Danilova
Jan 16, 2009·The Journal of Infectious Diseases·Manish SagarThomas C Quinn
Mar 24, 2017·AIDS Research and Therapy·Jan WeberMiguel E Quiñones-Mateu
Jun 29, 2001·AIDS Research and Human Retroviruses·R HandemaM Ito
Mar 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Friederike JochimsenGerd Walz
Mar 3, 2007·AIDS Research and Human Retroviruses·Milan ReinisHarold Burger
Dec 29, 2010·PLoS Pathogens·Marcel E CurlinJames I Mullins
Sep 20, 2001·The Journal of General Virology·C CasadoC López-Galíndez
Oct 27, 2007·AIDS Research and Human Retroviruses·Gonzalo BelloCecilio López-Galíndez
Jun 4, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kimdar Sherefa KemalHarold Burger
Mar 23, 2011·AIDS Research and Human Retroviruses·Jason T BlackardKenneth E Sherman
Aug 22, 2009·Journal of Medical Virology·Gonzalo BelloMariza G Morgado
Jun 5, 1999·AIDS Research and Human Retroviruses·F VerrierM Girard

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