PMID: 113672May 1, 1979

In vivo sister-chromatid exchange: a sensitive measure of DNA damage

Mutation Research
Y Nakanishi, E L Schneider

Abstract

A variety of chemical agents and X-irradiation were examined for their abilities to induce sister-chromatid exchanges (SCE) in vivo. In addition to demonstrating that several known mutagens and carcinogens are capable of inducing SCE in vivo, our studies indicate that the suspected carcinogen, tris-bromophosphate, can significantly elevate SCE levels. Comparison of the effects of these agents on SCE levels, chromosomal-aberration frequencies and cell-replication kinetics reveals that no consistent relationship exists between SCE levels and other indicators of cellular DNA damage. It is proposed that analysis of SCE induction in vivo may provide a useful technique for the screening of mutagenic and carcinogenic compounds.

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Citations

Jan 1, 1982·Radiation and Environmental Biophysics·J P Chaudhuri
Jan 1, 1982·Breast Cancer Research and Treatment·J RussoI H Russo
Jun 1, 1983·Mutation Research·R SeshadriA A Morley
Feb 1, 1979·Mechanisms of Ageing and Development·E L SchneiderM L Nieder
Sep 1, 1979·Mutation Research·M HollsteinW W Nichols
Jul 1, 1981·Mutation Research·S A LattS Wolff
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
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May 19, 2005·Cancer Genetics and Cytogenetics·Sükrü OztürkReyhan Diz Küçükkaya
Mar 24, 2004·Mutation Research·Gokay BozkurtCetin Algunes
Dec 20, 2000·Cancer Genetics and Cytogenetics·S OztürkY Perkçelen
Feb 13, 2003·Mutation Research·Gokay BozkurtCetin Algunes
Feb 27, 2001·Mutation Research·A D Bolzán, M S Bianchi
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·R Tanner HagelstromSusan M Bailey
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May 7, 2013·Chinese Medicine·Fotini PapachristouAlexandra K Tsaroucha
Jul 6, 2005·The Tohoku Journal of Experimental Medicine·Mustafa YildirimErhan Varoglu
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Sep 9, 2006·The Journal of Dermatology·Ali Karaman, Cihangir Aliağaoğlu
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