In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna

Bone
Matthew J SilvaMichael J Welch

Abstract

The skeletal response to damaging fatigue loading is not fully understood. We used (18)F-fluoride PET to describe the time course of the skeletal response following the creation of increasing levels of in vivo, fatigue-induced damage. The right forelimbs of 40 adult rats were loaded in vivo in cyclic compression to four levels of subfracture, fatigue displacement: 30, 45, 65, or 85% of fracture displacement. Rats were injected with a bone-seeking radionuclide ((18)F-fluoride) on days 0 (4 h), 2, 4, 7, 9, 11, 18, 24, and 30, and imaged using a small animal positron emission tomography (PET) scanner. We quantified fluoride uptake in the central 50% of the right (loaded) and left (control) forelimbs. There were significant increases in fluoride uptake in loaded forelimbs compared to control on day 0 for all displacement groups. Normalized uptake (loaded/control) reached peak levels 4 to 9 days after loading. Normalized uptake depended significantly on the level of fatigue displacement. Normalized uptake increased progressively from the 30 to the 45% displacement level (P < 0.001), and from the 45 to the 65% level (P < 0.001) but did not differ between 65 and 85% (P = 0.41). Histologically, we observed a rapid periosteal response w...Continue Reading

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Citations

Jun 7, 2007·Calcified Tissue International·Hironori MatsuzakiMatthew J Silva
Jul 26, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ryan E TomlinsonKooresh I Shoghi
Aug 25, 2011·AJR. American Journal of Roentgenology·Laura A DrubachEdwin L Palmer
Jun 26, 2013·AJR. American Journal of Roentgenology·Andrew WilmotPhilipp Mayer-Kuckuk
Nov 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Johannes CzerninChristiaan Schiepers
Feb 11, 2015·Connective Tissue Research·Atharva A Poundarik, Deepak Vashishth
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Jan 5, 2010·Trends in Biotechnology·Marie K ReumannPhilipp Mayer-Kuckuk
Apr 30, 2008·Journal of the Mechanical Behavior of Biomedical Materials·Huijie LengRyan K Roeder
Jun 20, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Brian A UthgenanntMatthew J Silva
Nov 16, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthew J Silva, Daniel C Touhey
Jun 30, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rhonda PrisbyMarie-Hélène Lafage-Proust
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Apr 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhan-Chun LiLi-Yang Dai

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