In vivo skin optical clearing by glycerol solutions: mechanism

Journal of Biophotonics
Xiang WenDan Zhu

Abstract

The penetration of light in biological tissues can be enhanced by using optical-clearing techniques. However, researches on the mechanism are limited to in vitro experiments. In this study, rat dorsal skin was used to discuss the mechanism for in vivo optical clearing. Glycerol solutions with different concentrations were applied by dermal injection; then the skin reflectance spectrum, SHG imaging and microstructural changes were monitored. The results showed that with the skin becoming transparent, the corresponding reflectance decreased, and the thickness of dermis and diameter of collagen fibril decreased, but no collagen fiber was dissolved or fractured. Hence, it can be concluded that the thickness decrease of dermis and corresponding more regular packing of tissue fibers plays an important role in the mechanism for glycerol-induced optical clearing of skin in vivo.

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Citations

Nov 25, 2011·Journal of Biomedical Optics·Yih Miin LiewDavid D Sampson
Aug 31, 2010·Journal of Biomedical Optics·Christina E RommelJürgen Schnekenburger
Nov 9, 2010·Journal of Biomedical Optics·Luís OliveiraValery V Tuchin
Jan 11, 2011·Journal of Innovative Optical Health Sciences·William C VogtChristopher G Rylander
Jan 1, 2010·Journal of Innovative Optical Health Sciences·Narendran SudheendranKirill V Larin
Dec 23, 2016·Journal of Biophotonics·Rui ShiDan Zhu
Jan 31, 2017·Journal of Biophotonics·Anton SdobnovValery Tuchin
Jun 15, 2018·Journal of Biomedical Optics·Kirby R CampbellPaul J Campagnola
Jun 24, 2016·Journal of Biomedical Optics·Yanmei LiangXingde Li
Dec 19, 2013·Laser & Photonics Reviews·Dan ZhuValery V Tuchin
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Jun 1, 2020·Bioelectricity·Cassandra L MartinJeffrey A Paten
Sep 11, 2021·Vascular Pharmacology·Jingtan ZhuDan Zhu

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