In Vivo Spectrum of UVC-induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers

Photochemistry and Photobiology
Hironobu IkehataMasayuki Yamamoto

Abstract

Although ultraviolet radiation (UVR) has a genotoxicity for inducing skin cancers, the skin may tolerate UVC component because the epidermal layer prevents this short wavelength range from passing through. Here, UVC genotoxicity for mouse skin was evaluated in terms of DNA damage formation and mutagenicity. UVC induced UVR photolesions and mutations remarkably in the epidermis but poorly in the dermis, confirming the barrier ability of the epidermis against shorter UVR wavelengths. Moreover, the epidermis itself responded to UVC mutagenicity with mutation induction suppression, which suppressed the mutant frequencies to a remarkably low, constant level regardless of UVC dose. The mutation spectrum observed in UVC-exposed epidermis showed a predominance of UV-signature mutation, which occurred frequently in 5'-TCG-3', 5'-TCA-3' and 5'-CCA-3' contexts. Especially, for the former two contexts, the mutations recurred at several sites with more remarkable recurrences at the 5'-TCG-3' sites. Comparison of the UVC mutation spectrum with those observed in longer UVR wavelength ranges led us to a mechanism that explains why the sequence context preference of UV-signature mutation changes according to the wavelength, which is based on th...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E BrashJ Pontén
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A GossenJ Vijg
Feb 1, 1988·Photochemistry and Photobiology·H J SterenborgJ C van der Leun
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E A DrobetskyB W Glickman
Mar 5, 1985·Journal of Molecular Biology·J H Miller
Jul 1, 1993·Trends in Genetics : TIG·A P Grollman, M Moriya
Nov 2, 1999·Journal of Molecular Biology·Y H YouG P Pfeifer
Oct 16, 2002·Mutation Research·Hironobu Ikehata, Tetsuya Ono
Jan 15, 2003·The Journal of Biological Chemistry·Dong-Hyun Lee, Gerd P Pfeifer
Apr 30, 1963·Biochimica Et Biophysica Acta·R A DEERING, R B SETLOW
Sep 3, 2004·The Journal of Biological Chemistry·Satoshi NakajimaAkira Yasui
Jan 26, 2005·Current Biology : CB·Judith JansGijsbertus T J van der Horst
Mar 8, 2005·Mutation Research·Jean CadetThierry Douki
Oct 26, 2005·Environmental and Molecular Mutagenesis·Feng WangHironobu Ikehata
Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stéphane MouretThierry Douki
Mar 22, 2008·The Journal of Investigative Dermatology·Hironobu IkehataTetsuya Ono
Mar 26, 2011·Journal of Radiation Research·Hironobu Ikehata, Tetsuya Ono
May 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ahmad BesaratiniaGerd P Pfeifer
Oct 7, 2011·The Journal of Investigative Dermatology·Angela TewariAntony R Young
Mar 9, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hironobu IkehataAkimichi Morita
Oct 30, 2014·Photochemistry and Photobiology·Douglas E Brash

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Citations

Feb 22, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hironobu IkehataMasayuki Yamamoto
Jun 1, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hironobu Ikehata
Feb 7, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jean Cadet, Thierry Douki
Aug 20, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Luke HortonHenry W Lim
Jan 23, 2021·Photochemistry and Photobiology·Nozomi YamanoChikako Nishigori

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