In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent

Toxicology
C XuC E Carter

Abstract

In vivo CdCl2-induced apoptotic DNA fragmentation in the testes of the male Wistar rat has been demonstrated on agarose gel. Characteristic DNA migration patterns (laddering) provide evidence of apoptosis (programmed cell death) in testicular tissue of rats administered CdCl2 at a level of 0.03 mmol/kg 48 h previously. Evidence that administration of an appropriate cadmium chelating agent within the first 24 h can suppress some or all of the apoptotic changes in testicular DNA has also been obtained for the first time. A greater reduction in apoptosis is observed as the interval between the administration of the cadmium and that of the chelating agent is shortened. Administration of monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) to male Wistar rats given CdCl2 is effective in the modulation of the typically apoptotic DNA fragmentation and associated histopathologic injury when the antagonist is given within approximately 1 h after the CdCl2 exposure. When the antagonist is given at later times there is a progressively more pronounced degradation of the DNA into oligonucleotides as seen in the typical electrophoretic DNA ladder pattern found with apoptosis. There is also a progressive increase in histopathological tissue cha...Continue Reading

References

Dec 1, 1977·The Journal of Pathology·M E Elmes
Aug 15, 1987·Analytical Biochemistry·J HattoriD A Johnson
Jan 1, 1980·Cell and Tissue Research·M E Elmes, J G Jones
Jul 1, 1995·Journal of Toxicology and Environmental Health·C XuP K Singh
Mar 11, 1994·Toxicology·B el AzzouziY Thomas
Apr 1, 1986·Immunology Today·E Duvall, A H Wyllie

❮ Previous
Next ❯

Citations

May 9, 2008·Apoptosis : an International Journal on Programmed Cell Death·Amrita M NargundJohn E Houghton
Oct 31, 2006·Environmental Monitoring and Assessment·Canan Soyer, Merih Bayram
Dec 2, 2006·Veterinary Research Communications·M Arabi, A A Mohammadpour
Oct 29, 2003·Toxicology·Michael WaisbergDetmar Beyersmann
Jan 15, 1997·Toxicology·M M JonesP A Ladd
Aug 24, 1999·Reproductive Toxicology·S BlottnerF Tataruch
Jul 1, 1999·Environmental Toxicology and Pharmacology·S Homma-TakedaN Shimojo
Apr 18, 2012·Nature Reviews. Urology·Katherine A McGlynn, Britton Trabert
Jul 9, 2002·Clinical and Experimental Immunology·H de la FuenteR González-Amaro
Jan 30, 2003·Journal of Toxicology and Environmental Health. Part a·Masato NiitsuyaMakato Kotani
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·K G CoonseS J Heggland
Nov 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Young-Ok SonXianglin Shi
Jan 25, 2008·Acta Pharmacologica Sinica·Wen-hsiung Chan, Nion-heng Shiao
Apr 20, 2007·Cell Stress & Chaperones·Maria AgnelloMaria C Roccheri
Jul 1, 2009·International Journal of Molecular Sciences·Ming-Shu HsiehWen-Hsiung Chan
Mar 1, 2014·Neurotoxicity Research·Hong LiuRichard Salvi
Sep 15, 2014·Environmental Toxicology and Pharmacology·Ali A AlshatwiAbdulrahmann S Al-Khalifa
Feb 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Elzbieta BondaAlicja Krasowska
Apr 20, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Takahiko KusakabeTakeaki Nagamine
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Ying Liu, Douglas M Templeton
May 26, 2009·Gynécologie, obstétrique & fertilité·P Marchetti, C Marchetti
Oct 12, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Neelam Yadav, Shashi Khandelwal
Jul 29, 2003·Journal of Applied Toxicology : JAT·Lars H PedersenMark J West
May 29, 2008·Journal of Cellular Physiology·Ying Liu, Douglas M Templeton
Oct 27, 2004·Toxicology Letters·Tong ZhouEdward M Eddy
Jun 30, 2004·Molecular and Cellular Endocrinology·Ronojoy Sen GuptaJaemog Soh
Jul 1, 2006·Environmental Toxicology and Pharmacology·Katharine M W Haberstroh, Carolyn M Kapron
May 9, 2000·Biochemical Pharmacology·M MatsuokaH Igisu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis