In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22

BMC Biology
François Karch

Abstract

Mutations in the proteins that bind insulator DNA elements that define the boundaries of chromatin domains can give morphogenetic readouts in Drosophila, as recently reported in BMC Biology by Bonchuk et al. in the Georgiev laboratory. But disentangling the effects on the phenotype may not be simple.See research article: http://www.biomedcentral.com/1741-7007/13/63.

References

Mar 25, 2006·Development·Robert K Maeda, François Karch
Jul 10, 2007·PLoS Genetics·Eimear E HolohanRobert White
Feb 1, 2008·Nature·Kerstin S WendtJan-Michael Peters
Jul 7, 2012·Genome Research·Yuri B SchwartzVincenzo Pirrotta
Nov 28, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Darya ChetverinaPaul Schedl
Mar 13, 2014·Nature Reviews. Genetics·Chin-Tong Ong, Victor G Corces

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Citations

Apr 19, 2016·Epigenetics & Chromatin·Cary StellohSridhar Rao

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